Apigenin is a natural flavonoid found in plants like chamomile and parsley. Its primary relevance to healthspan involves its potential to inhibit the CD38 enzyme, which degrades NAD+, a crucial coenzyme for cellular energy and repair. It also exhibits anti-inflammatory and mild senolytic properties in preclinical models, suggesting multiple pathways for supporting cellular health during aging.
Verdict
A safe but speculative supplement for NAD+ support and inflammation.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Low
EVIDENCE GRADE
C
MONTHLY COST
$15 - $30
Protocol
- A typical dose is 50mg taken once daily, often in the evening for its calming effects.
Flags
- May cause drowsiness; use caution when driving or operating machinery.
- Potential interactions with blood thinners, sedatives, and drugs metabolized by CYP enzymes.