Meta Information
ID:apigenin
Name:Apigenin
Schema Version:1.5
Title
Apigenin
Alternate Names
Empty Array
Intervention Type
therapeutic_agent
Expected Cost Mean
Low Cost:
15
High Cost:
30
Cost Type:
monthly
Description:
Cost for a one to two month supply of 50mg capsules.
Summary
Apigenin is a natural flavonoid found in plants like chamomile and parsley. Its primary relevance to healthspan involves its potential to inhibit the CD38 enzyme, which degrades NAD+, a crucial coenzyme for cellular energy and repair. It also exhibits anti-inflammatory and mild senolytic properties in preclinical models, suggesting multiple pathways for supporting cellular health during aging.
Purpose
A plant flavonoid that may support NAD+ levels and reduce inflammation.
Card Summary
A plant-derived flavonoid that may support cellular health by inhibiting the NAD+-degrading enzyme CD38, reducing inflammation, and exerting mild senolytic effects.
Drug Class
Drugs In Class
Empty Array
Impact
Score:
3.8
Justification:
Promising mechanisms (CD38 inhibition) but lacks robust human data for longevity outcomes.
Evidence
Grade:
C
Score:
3.5
Justification:
Primarily supported by preclinical (in-vitro/animal) data for core longevity mechanisms.
Safety
Score:
2.5
Justification:
Generally recognized as safe (GRAS) with a long history of human consumption.
Flags
- May cause drowsiness; use caution when driving or operating machinery.
- Potential interactions with blood thinners, sedatives, and drugs metabolized by CYP enzymes.
Verdict
A safe but speculative supplement for NAD+ support and inflammation.
Created
2026-04-23T22:54:00.823017Z
Model
Gemini 3.1 Pro (High)
Delivery
Route:
oral
Scope:
- systemic
Indication
Focus:
healthspan
Description:
Apigenin is a natural flavonoid found in plants like chamomile and parsley. Its primary relevance to healthspan involves its potential to inhibit the CD38 enzyme, which degrades NAD+, a crucial coenzy...
Typical Protocol
- A typical dose is 50mg taken once daily, often in the evening for its calming effects.