Akkermansia muciniphila is a gut bacterium that strengthens the intestinal lining by consuming and stimulating mucin production. Its metabolites, like short-chain fatty acids, reduce inflammation and improve metabolic health, which are key factors in healthspan.
Verdict
A promising probiotic for improving gut barrier and metabolic health.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$60 - $100
Protocol
- Daily supplementation with 10-100 billion AFUs (Active Fluorescent Units) is common.
Flags
- Use with caution in immunocompromised individuals due to theoretical risk of bacteremia.
- Initial gastrointestinal side effects like gas or bloating may occur.
- Pasteurized (heat-killed) forms may offer greater metabolic benefits and safety.