Meta Information

ID:akkermansia-muciniphila

Name:Akkermansia Muciniphila

Schema Version:1.5

Alternate Names

• A. muciniphila
• Akkermansia

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

60

High Cost:

100

Cost Type:

monthly

Description:

Cost for a 30-day supply of a high-quality probiotic supplement.

Summary

Akkermansia muciniphila is a gut bacterium that strengthens the intestinal lining by consuming and stimulating mucin production. Its metabolites, like short-chain fatty acids, reduce inflammation and improve metabolic health, which are key factors in healthspan.

Purpose

A next-generation probiotic to enhance gut barrier integrity and metabolic health.

Card Summary

A next-generation probiotic that resides in the gut's mucus layer, strengthening the intestinal barrier and producing beneficial metabolites to improve metabolic health and reduce inflammation.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

5.5

Justification:

Improves gut barrier and metabolic markers, but direct longevity evidence is limited.

Evidence

Grade:

B

Score:

6.5

Justification:

Human RCTs show benefits for metabolic health, but longevity-specific data is lacking.

Safety

Score:

2.5

Justification:

Generally recognized as safe (GRAS), but caution advised for the immunocompromised.

Flags

• Use with caution in immunocompromised individuals due to theoretical risk of bacteremia.
• Initial gastrointestinal side effects like gas or bloating may occur.
• Pasteurized (heat-killed) forms may offer greater metabolic benefits and safety.

Verdict

A promising probiotic for improving gut barrier and metabolic health.

Created

2026-04-27T01:02:27.642276Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Akkermansia muciniphila is a gut bacterium that strengthens the intestinal lining by consuming and stimulating mucin production. Its metabolites, like short-chain fatty acids, reduce inflammation and ...

Typical Protocol

• Daily supplementation with 10-100 billion AFUs (Active Fluorescent Units) is common.