Meta Information
ID:akkermansia-muciniphila
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/polyphenol-rich-foods
Target name:
Polyphenol-Rich Foods (e.g., Berries, Pomegranate, Green Tea, Dark Chocolate)
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Polyphenols from certain plant foods can act as prebiotics that selectively increase the abundance and activity of Akkermansia muciniphila in the gut.
Actionable advice:
Take with a meal or beverage rich in polyphenols like berries, pomegranate, green tea, or cocoa to enhance efficacy.
Target id:
/intervention/metformin_systemic_healthspan
Target name:
Metformin
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Metformin has been shown to increase the native population of Akkermansia in the gut; co-administration may amplify the metabolic benefits associated with both interventions.
Actionable advice:
Take at the same time as Metformin to potentially amplify shared metabolic benefits.
Target id:
/class/glp-1-receptor-agonists
Target name:
GLP-1 Receptor Agonists (e.g., Semaglutide, Tirzepatide)
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
GLP-1 agonists improve metabolic health and have been shown to increase the abundance of Akkermansia; co-supplementation may enhance these positive effects on the gut-metabolic axis.
Actionable advice:
Taking Akkermansia alongside GLP-1 medications may provide additive benefits for metabolic health.
Target id:
/class/sglt2-inhibitors
Target name:
SGLT2 Inhibitors (e.g., Empagliflozin, Canagliflozin)
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Evidence suggests SGLT2 inhibitors can favorably modulate the gut microbiome, including increasing Akkermansia levels, potentially leading to synergistic metabolic benefits.
Actionable advice:
May be taken together with SGLT2 inhibitors to support shared goals of metabolic health improvement.
Target id:
/class/antibiotics-long-term
Target name:
Antibiotics (Broad-Spectrum)
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Broad-spectrum antibiotics disrupt the entire gut microbiome, creating an ecosystem where the signaling and supportive effects of supplemental Akkermansia may be significantly blunted.
Actionable advice:
Effectiveness may be reduced during and immediately after a course of broad-spectrum antibiotics.
Target id:
/dietary/high-fat-meal
Target name:
High Saturated Fat Diet
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Diets high in saturated fat are associated with decreased natural abundance of Akkermansia and may promote a gut environment that counteracts the benefits of supplementation.
Actionable advice:
Avoid a diet high in saturated and processed fats to maximize the benefits of Akkermansia.
Target id:
/dietary/alcohol-acute
Target name:
Excessive Alcohol Consumption
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Chronic or excessive alcohol intake damages the gut lining and disrupts the microbiome, which can negate the gut-barrier-strengthening effects of Akkermansia.
Actionable advice:
Limit alcohol consumption to support a healthy gut environment for Akkermansia to be effective.
Target id:
/condition/immunocompromised
Target name:
Severely Immunocompromised State
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Although commercial supplements are typically pasteurized (non-viable), introducing any microbial component or modulator into a severely compromised immune system carries theoretical risks.
Actionable advice:
Consult a physician before use if you are severely immunocompromised (e.g., post-transplant, on high-dose immunosuppressants).
Target id:
/class/chemotherapy-radiation
Target name:
Active Cancer Therapy (Chemotherapy, Radiation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Cancer therapies can severely compromise the gut barrier (mucositis) and immune function, making the introduction of any microbiome-modulating agent a potential and unpredictable risk.
Actionable advice:
Avoid during active chemotherapy or radiation therapy unless specifically approved by your oncologist.
Target id:
/intervention/inulin
Target name:
Prebiotic Fiber (e.g., Inulin, FOS)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
While Akkermansia primarily consumes mucin, a gut environment rich in diverse prebiotics supports a healthier overall microbiome that can indirectly benefit Akkermansia populations.
Actionable advice:
Consider taking alongside a prebiotic fiber source to support overall gut microbiome health.
Target id:
/class/proton-pump-inhibitors
Target name:
Proton Pump Inhibitors (Long-term use)
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Long-term use of PPIs alters the gut pH and can lead to microbiome dysbiosis, potentially creating a less favorable environment for Akkermansia to exert its effects.
Actionable advice:
Be aware that long-term PPI use might slightly reduce the overall ecosystem benefits of Akkermansia supplementation.
Target id:
/dietary/meal
Target name:
Any Meal
Severity:
minor
Interaction type:
requirement
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
While pasteurized Akkermansia is not destroyed by stomach acid, taking it with food can improve tolerance and provides an opportunity to consume synergistic dietary components like polyphenols.
Actionable advice:
For consistency and to leverage dietary synergies, it is best to take with a meal.