Meta Information
ID:aged-garlic-extract
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Aged garlic extract possesses antiplatelet properties that can add to the effects of blood-thinning medications, significantly increasing the risk of bruising and serious bleeding events.
Actionable advice:
Avoid concurrent use with blood-thinning medications unless explicitly approved and monitored by your physician.
Target id:
/procedure/surgery
Target name:
Surgical Procedures
Severity:
major
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
168
Hours after target:
null
Description:
Due to its antiplatelet (blood-thinning) effects, aged garlic extract can increase the risk of excessive bleeding during and after surgical or dental procedures.
Actionable advice:
Discontinue use at least 7 days prior to any scheduled surgery and inform your surgeon of its use.
Target id:
/class/antiretrovirals
Target name:
Antiretroviral Medications (for HIV)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Garlic components can induce the CYP3A4 metabolic enzyme, which may accelerate the breakdown of certain antiretroviral drugs (especially protease inhibitors like saquinavir), reducing their blood levels and effectiveness.
Actionable advice:
Avoid aged garlic extract if you are taking antiretroviral medications for HIV treatment.
Target id:
/class/immunosuppressants
Target name:
Calcineurin Inhibitors
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Aged garlic extract may induce the CYP3A4 enzyme, accelerating the metabolism of critical immunosuppressants like tacrolimus and cyclosporine, which could lead to sub-therapeutic levels and risk of organ rejection.
Actionable advice:
Do not take aged garlic extract if you are on immunosuppressant therapy following an organ transplant.
Target id:
/condition/bleeding-disorders
Target name:
Bleeding Disorders
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The inherent antiplatelet activity of aged garlic extract can exacerbate bleeding tendencies in individuals with conditions like hemophilia or von Willebrand disease.
Actionable advice:
Avoid aged garlic extract completely if you have any diagnosed bleeding disorder.
Target id:
/intervention/isoniazid
Target name:
Isoniazid
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Aged garlic extract has been shown to interfere with the absorption and reduce the bioavailability of isoniazid, a primary medication for treating tuberculosis, potentially leading to treatment failure.
Actionable advice:
Avoid taking aged garlic extract concurrently with isoniazid.
Target id:
/class/antihypertensives
Target name:
Antihypertensive Medications
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Aged garlic extract can lower blood pressure. When combined with antihypertensive drugs, this effect is additive and may lead to hypotension (dizziness, fainting).
Actionable advice:
Monitor your blood pressure closely when combining with blood pressure medications and consult your doctor.
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Aged garlic extract may have a mild blood sugar-lowering effect, which can be additive with diabetes medications, increasing the risk of hypoglycemia (low blood sugar).
Actionable advice:
Monitor blood glucose levels carefully if combining with diabetes medications and be aware of hypoglycemic symptoms.
Target id:
/class/cyp3a4-substrates
Target name:
CYP3A4 Substrates
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Aged garlic extract may mildly induce the CYP3A4 liver enzyme, which could potentially increase the breakdown and reduce the effectiveness of a wide range of medications.
Actionable advice:
Consult a pharmacist or doctor to review for interactions if you take any prescription medications.
Target id:
/class/statins
Target name:
Statins (HMG-CoA Reductase Inhibitors)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Aged garlic extract has modest lipid-lowering effects that can complement the action of statin medications, potentially contributing to improved overall cholesterol management.
Actionable advice:
Inform your doctor of your use, as it may contribute to your overall lipid management strategy.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Taking aged garlic extract with food can help minimize potential mild gastrointestinal side effects, such as stomach upset or garlic-related odor, improving overall tolerability.
Actionable advice:
Take aged garlic extract with a meal to improve tolerability.