3-Hydroxyanthranilic Acid (3-HAA) is a metabolite of the amino acid tryptophan, produced via the kynurenine pathway. In animal models like C. elegans and mice, it has been shown to extend lifespan, likely by activating the NRF2 transcription factor which boosts endogenous antioxidant defenses. Its relevance and safety for human healthspan are entirely unknown and currently speculative.
Verdict
A purely experimental compound with no human data; not for use.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Very High
EVIDENCE GRADE
C
MONTHLY COST
$0 - $0
Protocol
- No established human protocol exists; this is a research chemical not intended for consumption.
Flags
- Not intended for human consumption and sold only as a research chemical.
- Human safety profile for supplementation is completely unknown.
- All evidence for lifespan extension comes from non-human animal models.
- Part of the kynurenine pathway, which is complex and linked to inflammation.