Meta Information
ID:vitamin-e
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/dietary/high-fat-meal
Target name:
Meal Containing Fat
Severity:
major
Interaction type:
requirement
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
As a fat-soluble vitamin, Vitamin E requires the presence of dietary fat and bile acids for proper absorption in the small intestine.
Actionable advice:
Always take Vitamin E supplements with a meal that contains some fat (e.g., avocado, nuts, olive oil).
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets (e.g., Warfarin, Aspirin)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Vitamin E has antiplatelet properties and can interfere with vitamin K-dependent clotting factors, significantly increasing the risk of bleeding when combined with these medications.
Actionable advice:
Avoid high-dose Vitamin E supplements (over 400 IU/day) if you are taking blood-thinning medications; consult your doctor.
Target id:
/procedure/surgery
Target name:
Upcoming Surgery
Severity:
major
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
336
Hours after target:
null
Description:
Due to its blood-thinning effects, Vitamin E can increase the risk of excessive bleeding during and after surgical procedures.
Actionable advice:
Discontinue Vitamin E supplements at least 2 weeks before any scheduled surgery.
Target id:
/condition/bleeding-disorders
Target name:
Bleeding Disorders or Vitamin K Deficiency
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Individuals with pre-existing bleeding disorders or vitamin K deficiency are highly susceptible to the anticoagulant effects of Vitamin E, leading to a high risk of spontaneous bleeding.
Actionable advice:
Avoid Vitamin E supplementation if you have a bleeding disorder or are vitamin K deficient.
Target id:
/condition/history-of-hemorrhagic-stroke
Target name:
History of Hemorrhagic Stroke
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Due to its anticoagulant properties, high-dose Vitamin E supplementation may increase the risk of a recurrent hemorrhagic stroke.
Actionable advice:
Avoid high-dose Vitamin E supplements if you have a history of hemorrhagic stroke.
Target id:
/condition/retinitis-pigmentosa
Target name:
Retinitis Pigmentosa
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Clinical trial data suggests that high-dose Vitamin E supplementation (400 IU/day) may accelerate the progression of vision loss in individuals with retinitis pigmentosa.
Actionable advice:
Avoid Vitamin E supplements if you have been diagnosed with retinitis pigmentosa.
Target id:
/class/chemotherapy-radiation
Target name:
Chemotherapy and Radiation Therapy
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
The potent antioxidant activity of Vitamin E may interfere with the efficacy of cancer treatments that rely on generating oxidative stress to destroy malignant cells.
Actionable advice:
Avoid high-dose antioxidant supplements, including Vitamin E, during cancer treatment unless approved by your oncologist.
Target id:
/condition/prostate-cancer-risk
Target name:
High Risk for or History of Prostate Cancer
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The SELECT trial found that supplementation with 400 IU/day of synthetic Vitamin E was associated with an increased risk of prostate cancer in healthy men.
Actionable advice:
Men, especially those with a family history of prostate cancer, should avoid high-dose Vitamin E supplementation.
Target id:
/intervention/vitamin-k2
Target name:
Vitamin K
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
High doses of Vitamin E (typically >800 IU/day) can antagonize the action of Vitamin K, impairing the synthesis of blood clotting factors and increasing bleeding risk.
Actionable advice:
Avoid taking high doses of Vitamin E if you are deficient in Vitamin K or have other bleeding risk factors.
Target id:
/class/statins
Target name:
Statins (especially when combined with Niacin)
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
High-dose antioxidant cocktails containing Vitamin E have been shown to blunt the beneficial HDL-cholesterol-raising effects of statin and niacin combination therapy.
Actionable advice:
Discuss high-dose Vitamin E use with your doctor if you are taking statins, particularly with niacin.
Target id:
/class/bile-acid-sequestrants
Target name:
Bile Acid Sequestrants (e.g., Cholestyramine)
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
4
Hours after target:
4
Description:
These medications bind to bile acids in the intestine, which can also bind to and prevent the absorption of fat-soluble vitamins like Vitamin E.
Actionable advice:
Take Vitamin E at least 4 hours before or 4 hours after taking a bile acid sequestrant.
Target id:
/intervention/orlistat
Target name:
Orlistat (Alli, Xenical)
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Orlistat is a weight-loss drug that blocks the absorption of dietary fat, which consequently reduces the absorption of fat-soluble Vitamin E.
Actionable advice:
Separate Vitamin E doses from Orlistat by at least 2 hours.
Target id:
/class/immunosuppressants
Target name:
Cyclosporine
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
High doses of Vitamin E (especially as TPGS, a water-soluble form) can enhance the absorption of cyclosporine, potentially leading to toxic blood levels of the drug.
Actionable advice:
Avoid high-dose Vitamin E if taking cyclosporine; consult your doctor before combining them.
Target id:
/intervention/vitamin_c_systemic_healthspan
Target name:
Vitamin C
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Vitamin C can regenerate the antioxidant capacity of Vitamin E after it has neutralized a free radical, effectively recycling it for further use.
Actionable advice:
Taking Vitamin C and Vitamin E together can enhance their overall antioxidant effect.
Target id:
/intervention/selenium
Target name:
Selenium
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Selenium is a crucial component of the antioxidant enzyme glutathione peroxidase, which works in concert with Vitamin E to protect cell membranes from oxidative damage.
Actionable advice:
Co-administration of selenium and Vitamin E supports a comprehensive antioxidant defense system.
Target id:
/intervention/coenzyme-q10
Target name:
Coenzyme Q10 (CoQ10)
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Both Vitamin E and CoQ10 are lipid-soluble antioxidants that protect mitochondrial and other cellular membranes from lipid peroxidation.
Actionable advice:
Taking Vitamin E with CoQ10 provides complementary antioxidant protection within cell membranes.
Target id:
/class/iron-supplements
Target name:
Iron Supplements (especially inorganic forms)
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Inorganic iron (like ferrous sulfate) can promote the oxidation and destruction of Vitamin E in the digestive tract, potentially reducing its bioavailability.
Actionable advice:
Separate doses of Vitamin E and inorganic iron supplements by at least 2 hours.
Target id:
/class/anticonvulsants
Target name:
Enzyme-Inducing Anticonvulsants (e.g., Phenytoin, Phenobarbital)
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Certain older anticonvulsant medications can increase the metabolic breakdown of Vitamin E in the liver, potentially leading to lower serum levels over time.
Actionable advice:
If on long-term anticonvulsant therapy, consider monitoring Vitamin E levels with your doctor.
Target id:
/intervention/vitamin-a
Target name:
High-Dose Vitamin A
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Very high doses of Vitamin A can interfere with the absorption of other fat-soluble vitamins, including Vitamin E, as they compete for similar absorption pathways.
Actionable advice:
Avoid taking very high doses of both Vitamin A and Vitamin E simultaneously.