Meta Information
ID:vitamin-c
Name:
Schema Version:AIM-2.0
Created
2026-05-10T18:31:40.205700Z
Model
Gemini 3.1 Pro (High)
Interactions
Target id:
/condition/g6pd-deficiency
Target name:
G6PD Deficiency
Severity:
major
Interaction type:
contraindicated
Nature:
absolute
Description:
High intravenous doses of Vitamin C can cause severe red blood cell destruction (hemolysis).
Actionable advice:
Avoid high-dose intravenous Vitamin C.
Target id:
/class/chemotherapy-radiation
Target name:
Cytotoxic Cancer Therapies (Chemotherapy & Radiation)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
High-dose antioxidants may interfere with chemotherapy, potentially reducing its cancer-killing effectiveness.
Actionable advice:
Avoid antioxidant supplements during treatment.
Target id:
/condition/hemochromatosis
Target name:
Hemochromatosis (Iron Overload)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Vitamin C increases iron absorption, which can worsen iron overload in this condition.
Actionable advice:
Avoid Vitamin C supplements.
Target id:
/class/iron-supplements
Target name:
Iron Supplements
Severity:
major
Interaction type:
synergistic
Nature:
absolute
Description:
Vitamin C significantly enhances the absorption of non-heme iron, making supplements more effective.
Actionable advice:
Take iron with Vitamin C.
Target id:
/condition/chronic-kidney-disease
Target name:
Chronic Kidney Disease
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
High doses of Vitamin C can increase the risk of forming oxalate kidney stones.
Actionable advice:
Avoid high-dose Vitamin C supplements.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Very high doses of Vitamin C may decrease the effectiveness of anticoagulant drugs like warfarin.
Actionable advice:
Avoid high-dose Vitamin C with warfarin.
Target id:
/class/estrogens
Target name:
Estrogens and Progestins (Hormonal Therapy & Contraceptives)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Vitamin C can increase estrogen levels, potentially increasing side effects from hormonal therapy or contraceptives.
Actionable advice:
Monitor for estrogen-related side effects.
Target id:
/class/stimulants
Target name:
Stimulant Medications
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
Vitamin C acidifies urine, which can increase the excretion and reduce effectiveness of amphetamines.
Actionable advice:
Separate doses by at least 1 hour.
Target id:
/intervention/propranolol
Target name:
Propranolol
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
High doses of Vitamin C may decrease the absorption and effectiveness of propranolol.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/statins
Target name:
Statins
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
High-dose antioxidant supplements may slightly reduce the HDL-cholesterol-raising benefits of some statins.
Actionable advice:
Discuss high-dose antioxidant use with your doctor.
Target id:
/intervention/copper
Target name:
Copper
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Description:
High doses of Vitamin C can reduce the absorption of copper from supplements or food.
Actionable advice:
Separate doses by at least 2 hours.
Target id:
/intervention/low-dose-aspirin
Target name:
Low-Dose Aspirin
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
High-dose Vitamin C may decrease aspirin excretion, potentially increasing its levels and side effects.
Actionable advice:
Use caution with high-dose Vitamin C.
Target id:
/intervention/proton-pump-inhibitors
Target name:
Proton Pump Inhibitors
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Description:
Long-term use of acid-reducing drugs can slightly impair the absorption of Vitamin C.
Actionable advice:
Ensure adequate dietary Vitamin C intake.