Riboflavin is a crucial precursor to the coenzymes FAD and FMN, which are essential for cellular energy production via the electron transport chain and numerous metabolic redox reactions. Ensuring adequate riboflavin levels is foundational for maintaining mitochondrial function and overall metabolic health, preventing age-related decline associated with energy deficits.
Verdict
Essential nutrient best obtained from diet; supplement only if deficient.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
A
MONTHLY COST
$5 - $15
Protocol
- The Recommended Dietary Allowance (RDA) is 1.1-1.3 mg daily, typically met through a balanced diet.
- Supplementation is generally only necessary to correct a dietary deficiency or for specific medical indications.
- High doses of up to 400 mg daily are used under medical supervision for migraine prophylaxis.
Flags
- High doses cause a harmless, bright yellow-orange discoloration of urine (flavinuria).
- May interfere with certain lab tests, including urinalysis and catecholamine measurements.
- May decrease the absorption of tetracycline antibiotics; separate doses by several hours.