Meta Information
ID:uridine-monophosphate
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/antiretrovirals
Target name:
Antiretroviral Medications (for HIV)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Uridine competes with certain thymidine analog antiretroviral drugs (e.g., zidovudine, stavudine) for the same metabolic activation pathway, which could reduce their effectiveness against HIV.
Actionable advice:
Avoid uridine supplements completely if you are taking thymidine analog antiretroviral medications.
Target id:
/class/chemotherapy-radiation
Target name:
Pyrimidine Analog Chemotherapy
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Uridine can compete with or directly counteract the effects of chemotherapy drugs designed to disrupt pyrimidine metabolism (e.g., 5-Fluorouracil, Capecitabine), potentially reducing their cancer-fighting efficacy.
Actionable advice:
Avoid uridine supplements completely during treatment with pyrimidine analog chemotherapy unless specifically directed by your oncologist.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The safety of uridine monophosphate supplementation during pregnancy has not been established, and its effects on fetal development are unknown.
Actionable advice:
Avoid completely during pregnancy.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is unknown if supplemental uridine passes into breast milk or what its effects might be on a nursing infant; therefore, it should be avoided.
Actionable advice:
Avoid completely while breastfeeding.
Target id:
/class/choline-precursors
Target name:
Choline Precursors (e.g., Alpha-GPC, Citicoline)
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Uridine and choline are both essential precursors for the synthesis of phosphatidylcholine, a critical component of brain cell membranes, leading to enhanced synaptic formation and cognitive benefits.
Actionable advice:
Take together with a choline source like Alpha-GPC or Citicoline to support brain health.
Target id:
/intervention/omega-3-dha
Target name:
Omega-3 DHA
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
DHA is the specific fatty acid incorporated into neuronal membranes during phosphatidylcholine synthesis, a process promoted by uridine and choline.
Actionable advice:
Take together with a high-DHA fish oil or algal oil for optimal cognitive benefits.
Target id:
/intervention/folate
Target name:
Folate (Vitamin B9)
Severity:
moderate
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
null
Description:
Folate is essential for the one-carbon metabolism pathway, which provides methyl groups necessary for the synthesis and recycling of nucleotides like uridine.
Actionable advice:
Ensure adequate folate intake through diet or supplementation for optimal uridine utilization.
Target id:
/biomarker/vitamin-b12
Target name:
Vitamin B12
Severity:
moderate
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
null
Description:
Vitamin B12 is a critical cofactor in the methylation cycle, which is closely linked to nucleotide synthesis pathways that involve uridine.
Actionable advice:
Maintain sufficient Vitamin B12 levels to support the metabolic pathways that utilize uridine.
Target id:
/condition/hyperuricemia-gout
Target name:
Gout or High Uric Acid
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Uridine is a pyrimidine nucleoside, and its metabolism can contribute to the purine pool, potentially increasing uric acid production and exacerbating gout or high uric acid levels.
Actionable advice:
Use with caution and monitor uric acid levels if you have a history of gout or hyperuricemia.
Target id:
/condition/bipolar-disorder
Target name:
Bipolar Disorder
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
While uridine is being researched for bipolar disorder, unsupervised use could potentially alter mood states and interfere with prescribed treatments.
Actionable advice:
Do not use unless under the direct supervision of a psychiatrist.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
null
Description:
Uridine may promote sleep-related processes in the brain, and some users report a relaxing effect, making evening administration potentially beneficial for sleep quality.
Actionable advice:
Consider taking your dose 1 hour before bedtime to potentially enhance sleep quality.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Taking uridine with food can help minimize the risk of mild gastrointestinal discomfort that some individuals may experience.
Actionable advice:
Take with a meal to improve tolerability, though it is not required for absorption.
Target id:
/biomarker/uric-acid
Target name:
Uric Acid Levels
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
High doses of uridine can increase the metabolic production of uric acid, leading to elevated levels in blood tests.
Actionable advice:
Be aware that uridine supplementation may raise uric acid levels; regular monitoring is advised for long-term users.
Target id:
/condition/hepatic-impairment
Target name:
Hepatic Impairment
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The metabolism of uridine may be altered in individuals with liver disease, warranting caution.
Actionable advice:
Consult a healthcare professional before use if you have liver disease.
Target id:
/condition/renal-impairment
Target name:
Renal Impairment
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The clearance of uridine metabolites may be affected by kidney function, warranting caution in individuals with renal impairment.
Actionable advice:
Consult a healthcare professional before use if you have kidney disease.