Meta Information
ID:ubiquinol
Name:
Schema Version:AIM-3.0
Interactions
Target id:
/dietary/high-fat-meal
Target name:
Meal Containing Fat
Severity:
major
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
null
Description:
Ubiquinol is a fat-soluble compound, and its absorption from the small intestine is significantly increased when co-ingested with dietary fats which stimulate bile secretion.
Actionable advice:
Always take Ubiquinol with a meal that contains some fat or oil for optimal absorption.
Target id:
/dietary/fasting-state
Target name:
Empty Stomach / Fasting
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
As a fat-soluble molecule, Ubiquinol requires dietary fats to be properly absorbed; taking it without food results in very low bioavailability.
Actionable advice:
Avoid taking Ubiquinol on an empty stomach to ensure it is properly absorbed.
Target id:
/class/statins
Target name:
Statins
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Statin medications inhibit an enzyme (HMG-CoA reductase) that is required for the body's production of both cholesterol and Coenzyme Q10, leading to lower CoQ10 levels.
Actionable advice:
Consider supplementing with Ubiquinol when taking statins to replenish depleted levels and potentially reduce muscle-related side effects.
Target id:
/class/chemotherapy-radiation
Target name:
Chemotherapy and Radiation Therapy
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
The strong antioxidant properties of Ubiquinol may interfere with chemotherapy or radiation treatments that rely on generating oxidative stress to destroy cancer cells.
Actionable advice:
Avoid taking Ubiquinol during active chemotherapy or radiation therapy unless specifically approved by your oncologist.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants (e.g., Warfarin)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Ubiquinol is structurally similar to Vitamin K, a key factor in blood clotting, and may theoretically interfere with the action of anticoagulant drugs like warfarin, potentially decreasing their effectiveness.
Actionable advice:
Consult your doctor before taking Ubiquinol if you are on blood-thinning medication, as dose adjustments and monitoring may be necessary.
Target id:
/procedure/scheduled-surgery
Target name:
Scheduled Surgery
Severity:
moderate
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
336
Hours after target:
null
Description:
Ubiquinol may affect blood pressure and blood clotting, which could interfere with blood pressure control and increase bleeding risk during and after surgical procedures.
Actionable advice:
Discontinue Ubiquinol at least two weeks before any scheduled surgery and inform your surgeon.
Target id:
/intervention/pqq
Target name:
PQQ (Pyrroloquinoline quinone)
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
PQQ supports the creation of new mitochondria, while Ubiquinol is a critical component for energy production within existing mitochondria, creating a complementary effect for cellular energy.
Actionable advice:
Consider taking PQQ and Ubiquinol together to comprehensively support mitochondrial health and function.
Target id:
/intervention/omega-3-epa-dha
Target name:
Omega-3 Fatty Acids (Fish Oil)
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
As a fat-soluble nutrient, Ubiquinol's absorption is enhanced by the presence of fats, such as those provided by omega-3 supplements.
Actionable advice:
Take Ubiquinol at the same time as your omega-3 supplement to improve its absorption.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The safety of high-dose Ubiquinol supplementation during pregnancy has not been well-established, so its use is not recommended out of caution.
Actionable advice:
Avoid taking Ubiquinol supplements during pregnancy unless specifically advised by your doctor.
Target id:
/condition/lactation
Target name:
Lactation
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is unknown if supplemental Ubiquinol passes into breast milk in significant amounts or what its effects might be on a nursing infant.
Actionable advice:
Avoid taking Ubiquinol supplements while breastfeeding due to a lack of safety data.
Target id:
/class/antihypertensives
Target name:
Blood Pressure Lowering Medications
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Ubiquinol may have a mild blood pressure-lowering effect, which can add to the effects of antihypertensive medications, potentially increasing the risk of hypotension.
Actionable advice:
Monitor your blood pressure regularly if you combine Ubiquinol with blood pressure medication and consult your doctor.
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications (including Insulin)
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Ubiquinol may improve glucose metabolism and lower blood sugar levels, potentially enhancing the effects of diabetes medications and increasing the risk of hypoglycemia.
Actionable advice:
Monitor blood glucose levels closely if you take Ubiquinol with diabetes medication and consult your doctor.
Target id:
/intervention/vitamin-e
Target name:
Vitamin E
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Vitamin E and Ubiquinol are both fat-soluble antioxidants that work together to protect cell membranes, and Vitamin E can help recycle Coenzyme Q10 back to its active Ubiquinol form.
Actionable advice:
Taking Vitamin E and Ubiquinol together may provide enhanced antioxidant protection.
Target id:
/intervention/alcar
Target name:
Acetyl-L-Carnitine (ALCAR)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
L-Carnitine transports fuel (fatty acids) into the mitochondria, while Ubiquinol is essential for converting that fuel into cellular energy (ATP), making them a synergistic pair for energy metabolism.
Actionable advice:
Taking L-Carnitine and Ubiquinol together can support overall mitochondrial energy production.
Target id:
/circadian/sleep
Target name:
Bedtime / Sleep
Severity:
minor
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
4
Hours after target:
null
Description:
As Ubiquinol is central to cellular energy production, some individuals may find that taking it close to bedtime can be mildly stimulating and interfere with sleep.
Actionable advice:
If you are sensitive, consider taking your dose earlier in the day, such as with breakfast or lunch.