Meta Information

ID:tranexamic-acid

Name:Tranexamic Acid

Schema Version:1.5

Alternate Names

• TXA
• Lysteda
• Cyklokapron

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

20

High Cost:

100

Cost Type:

monthly

Description:

Generic oral or topical formulations; often requires a prescription and may be insurance-covered.

Summary

Tranexamic acid is an antifibrinolytic agent that prevents the breakdown of blood clots by inhibiting plasmin activation. Its primary relevance to healthspan is not systemic, but rather its topical application to treat melasma, a form of skin hyperpigmentation often associated with aging and sun exposure. There is no current evidence to support its systemic use for extending lifespan or improving general healthspan metrics.

Purpose

Antifibrinolytic agent used topically for skin hyperpigmentation (melasma).

Card Summary

A medication that prevents blood clot breakdown, used topically for skin hyperpigmentation (melasma) but has no systemic healthspan application.

Drug Class

antifibrinolytic

Drugs In Class

Empty Array

Impact

Score:

2.1

Justification:

Limited to topical cosmetic benefits (melasma); no systemic longevity evidence.

Evidence

Grade:

A

Score:

8.5

Justification:

Multiple human RCTs confirm efficacy for topical treatment of melasma.

Safety

Score:

6.5

Justification:

Systemic use carries a significant risk of thrombosis (blood clots).

Flags

• Systemic use significantly increases the risk of blood clots (thrombosis, stroke, pulmonary embolism).
• Requires a prescription and medical supervision for any use.
• Contraindicated in individuals with a history of or risk for thromboembolic disease.
• Interacts with hormonal contraceptives, further increasing clot risk.
• No evidence supports systemic use for longevity or anti-aging purposes.

Verdict

Topically useful for melasma; avoid systemic use for healthspan due to risks.

Created

2026-04-26T18:49:24.113972Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Is Skin Health

True

Indication

Focus:

healthspan

Description:

Tranexamic acid is an antifibrinolytic agent that prevents the breakdown of blood clots by inhibiting plasmin activation. Its primary relevance to healthspan is not systemic, but rather its topical ap...

Typical Protocol

• No established healthspan protocol exists; it is clinically used for bleeding disorders or topically for melasma.