Meta Information
ID:tranexamic-acid
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/estrogens
Target name:
Estrogens and Progestins (Hormonal Therapy & Contraceptives)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Both tranexamic acid and hormonal therapies (containing estrogen and/or progestin) independently increase the risk of blood clots. Using them together creates an additive and potentially dangerous risk of deep vein thrombosis, pulmonary embolism, or stroke.
Actionable advice:
Avoid using tranexamic acid concurrently with combined hormonal contraceptives or hormone replacement therapy.
Target id:
/condition/thromboembolic-disease-history
Target name:
History of Blood Clots (DVT, PE, Stroke)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Tranexamic acid prevents the breakdown of blood clots. In individuals with a personal history of venous or arterial clots, its use is contraindicated as it can increase the risk of a new thrombotic event.
Actionable advice:
Do not take tranexamic acid if you have a personal or strong family history of blood clots.
Target id:
/class/pro-coagulants
Target name:
Pro-coagulant Medications (e.g., Factor IX complex)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Combining tranexamic acid with medications that promote blood clotting, such as Factor IX complex or anti-inhibitor coagulant concentrates, significantly elevates the risk of widespread and potentially fatal thrombosis.
Actionable advice:
This combination is contraindicated and should only be managed by a hematologist in specific, monitored situations.
Target id:
/class/thrombolytics
Target name:
Thrombolytic Agents (Clot Busters)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Tranexamic acid is a direct pharmacological antagonist to thrombolytic drugs (e.g., alteplase). Tranexamic acid prevents clot breakdown, while thrombolytics are administered specifically to dissolve life-threatening clots.
Actionable advice:
Never take these medications together; they have directly opposing and mutually negating effects.
Target id:
/condition/renal-impairment
Target name:
Renal Impairment
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Tranexamic acid is cleared by the kidneys. In cases of renal impairment, the drug can accumulate to high levels, increasing the risk of side effects, most notably seizures.
Actionable advice:
Avoid tranexamic acid with severe renal impairment; dose reduction is required for mild to moderate impairment under medical supervision.
Target id:
/intervention/tretinoin-oral
Target name:
Oral Tretinoin (All-trans retinoic acid)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Concurrent use of tranexamic acid and oral tretinoin, particularly in patients with acute promyelocytic leukemia, has been associated with a potential for catastrophic thrombotic complications.
Actionable advice:
Avoid concomitant use of tranexamic acid and oral tretinoin unless specifically directed and monitored by a specialist.
Target id:
/condition/defective-color-vision
Target name:
Acquired Defective Color Vision
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Tranexamic acid can cause disturbances in color vision. It is contraindicated in individuals with a pre-existing acquired defect in color vision, as it would be impossible to detect this specific side effect.
Actionable advice:
Do not take tranexamic acid if you have an acquired defect in color vision.
Target id:
/condition/subarachnoid-hemorrhage
Target name:
Subarachnoid Hemorrhage
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
While tranexamic acid can reduce re-bleeding after a subarachnoid hemorrhage, clinical evidence suggests it may increase the risk of cerebral ischemia (stroke) and poor neurological outcomes.
Actionable advice:
Do not use tranexamic acid for a subarachnoid hemorrhage due to the risk of cerebral infarction.
Target id:
/condition/seizure-disorder
Target name:
Seizure Disorder / Epilepsy
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
High concentrations of tranexamic acid, particularly with rapid intravenous administration or in patients with kidney dysfunction, can lower the seizure threshold by acting as a GABA receptor antagonist.
Actionable advice:
Use with extreme caution or avoid in individuals with a history of seizures.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Tranexamic acid promotes clot stability (antifibrinolytic), while anticoagulants and antiplatelets prevent clot formation. Their mechanisms are opposing, and concurrent use can counteract the intended therapeutic effects of either agent.
Actionable advice:
Avoid using these medications together unless under the direct supervision of a physician for a specific clinical reason.
Target id:
/class/herbal-anticoagulants
Target name:
Herbal Anticoagulants/Antiplatelets
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Supplements with blood-thinning properties (e.g., ginkgo, garlic, high-dose fish oil, curcumin) work to prevent clotting, while tranexamic acid works to stabilize clots. Using them together may reduce the effectiveness of either the supplement or the medication.
Actionable advice:
It is prudent to discontinue supplements with blood-thinning effects while taking tranexamic acid.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
The absorption and effectiveness of oral tranexamic acid are not significantly affected by food. It can be taken with or without meals, which allows for flexible scheduling.
Actionable advice:
Take with food if it causes stomach upset; otherwise, timing with meals is not required.