Thiamine is an essential coenzyme critical for converting carbohydrates into ATP, the primary energy currency of the cell. By supporting key mitochondrial enzymes in the Krebs cycle, adequate thiamine levels are fundamental for metabolic health, nervous system function, and preventing age-related declines in cellular energy production.
Verdict
Essential for energy; supplement if diet is poor or risk factors exist.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$5 - $15
Protocol
- Daily oral supplementation of 50-100 mg is common for ensuring optimal cellular energy production.
Flags
- Deficiency is a significant risk in alcohol use disorder and post-bariatric surgery.
- Diuretic medications (e.g., furosemide) can increase urinary excretion and deficiency risk.
- High intake of tea, coffee, and raw shellfish can interfere with thiamine absorption.