Meta Information

ID:thiamine

Name:Vitamin B1 (Thiamine)

Schema Version:1.5

Alternate Names

• Thiamin

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

5

High Cost:

15

Cost Type:

monthly

Description:

Widely available and inexpensive over-the-counter oral supplement.

Summary

Thiamine is an essential coenzyme critical for converting carbohydrates into ATP, the primary energy currency of the cell. By supporting key mitochondrial enzymes in the Krebs cycle, adequate thiamine levels are fundamental for metabolic health, nervous system function, and preventing age-related declines in cellular energy production.

Purpose

Essential coenzyme for mitochondrial energy production and nervous system health.

Card Summary

A foundational B-vitamin essential for converting food into cellular energy, supporting mitochondrial and neurological health.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Essential for mitochondrial energy production, but supplementation benefits non-deficient individuals modestly.

Evidence

Grade:

B

Score:

7.5

Justification:

Extensive evidence for its essential metabolic role; less direct evidence for longevity extension.

Safety

Score:

2.5

Justification:

Water-soluble vitamin with a very high safety profile; excess is readily excreted.

Flags

• Deficiency is a significant risk in alcohol use disorder and post-bariatric surgery.
• Diuretic medications (e.g., furosemide) can increase urinary excretion and deficiency risk.
• High intake of tea, coffee, and raw shellfish can interfere with thiamine absorption.

Verdict

Essential for energy; supplement if diet is poor or risk factors exist.

Created

2026-04-26T17:38:58.812116Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Thiamine is an essential coenzyme critical for converting carbohydrates into ATP, the primary energy currency of the cell. By supporting key mitochondrial enzymes in the Krebs cycle, adequate thiamine...

Typical Protocol

• Daily oral supplementation of 50-100 mg is common for ensuring optimal cellular energy production.