Telmisartan is an Angiotensin II Receptor Blocker (ARB) that lowers blood pressure by blocking the vasoconstricting effects of angiotensin II. Uniquely among ARBs, it also acts as a partial PPAR-gamma agonist, which can improve insulin sensitivity and metabolic health, making it a dual-threat agent against cardiometabolic aging.
Verdict
A top-tier ARB for blood pressure control with unique metabolic benefits.
HEALTHSPAN IMPACT
High Value
RISK LEVEL
Moderate
EVIDENCE GRADE
A
MONTHLY COST
$10 - $25
Protocol
- Typical longevity-focused protocols involve daily doses of 20mg to 40mg, often taken at night.
Flags
- Contraindicated during pregnancy due to risk of fetal injury.
- Risk of hyperkalemia (high potassium), especially with kidney issues or potassium supplements.
- May cause hypotension (low blood pressure), dizziness, or lightheadedness.
- Rare but serious risk of angioedema (swelling).
- Requires a prescription and medical supervision.