Meta Information
ID:tb-500
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/condition/active-cancer
Target name:
Active Cancer
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
TB-500 promotes cell proliferation and angiogenesis (new blood vessel growth), which could theoretically accelerate the growth and spread of existing tumors.
Actionable advice:
Avoid completely if you have any active malignancy.
Target id:
/condition/proliferative-retinopathy
Target name:
Proliferative Retinopathy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
TB-500 promotes the formation of new blood vessels (angiogenesis), which could exacerbate conditions like diabetic retinopathy where abnormal vessel growth is the primary pathology.
Actionable advice:
Avoid completely if you have any form of proliferative retinopathy or macular degeneration.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The effects of TB-500 on fetal development are unknown, but its fundamental role in cell proliferation and angiogenesis poses a significant theoretical risk.
Actionable advice:
Avoid completely during pregnancy.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is unknown if TB-500 is excreted in breast milk or what its effects on a nursing infant would be; due to its biological activity, it is contraindicated.
Actionable advice:
Avoid completely while breastfeeding.
Target id:
/condition/history-of-cancer
Target name:
History of Cancer
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Due to its pro-proliferative and angiogenic properties, there is a theoretical risk of promoting the recurrence of a prior malignancy.
Actionable advice:
Use with extreme caution and only after thorough consultation with an oncologist.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
TB-500's role in tissue repair and blood vessel formation may theoretically alter platelet function and the coagulation process, potentially increasing bleeding risk.
Actionable advice:
Use with caution and monitor for signs of increased bruising or bleeding.
Target id:
/class/corticosteroids
Target name:
Corticosteroids
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Corticosteroids suppress the inflammatory and cellular processes necessary for tissue repair, potentially counteracting the healing and regenerative effects of TB-500.
Actionable advice:
Avoid concurrent use if possible, as corticosteroids may reduce the effectiveness of TB-500 for healing.
Target id:
/condition/autoimmune-disorders
Target name:
Active Autoimmune Disorders
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
TB-500 has complex immunomodulatory effects, including on T-cell maturation, which could unpredictably alter the course of an active autoimmune disease.
Actionable advice:
Use with extreme caution and under medical supervision if you have an active autoimmune condition.
Target id:
/intervention/bpc-157
Target name:
BPC-157
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
BPC-157 and TB-500 act on different but complementary pathways to promote tissue repair and reduce inflammation, potentially leading to enhanced healing when used together.
Actionable advice:
Consider co-administration for enhanced tissue repair, often in the same syringe.
Target id:
/class/ghrps-ghrhs
Target name:
Growth Hormone Secretagogues (e.g., Ipamorelin, CJC-1295)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Growth hormone and its downstream mediator IGF-1 are critical for tissue repair; combining TB-500 with agents that increase these hormones may enhance anabolic and regenerative processes.
Actionable advice:
May be used together to potentially accelerate recovery from injury.
Target id:
/intervention/collagen-peptides
Target name:
Collagen Peptides / Glycine
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Supplying key amino acids like glycine and proline from collagen provides the raw materials needed for the new tissue synthesis stimulated by TB-500.
Actionable advice:
Consider supplementing with collagen peptides or glycine to support the repair process.
Target id:
/intervention/zinc
Target name:
Zinc
Severity:
minor
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
null
Description:
Zinc is an essential mineral and enzymatic cofactor for cellular repair and protein synthesis, processes that TB-500 is intended to support.
Actionable advice:
Ensure adequate dietary or supplemental zinc intake to support the healing processes facilitated by TB-500.
Target id:
/intervention/vitamin_c_systemic_healthspan
Target name:
Vitamin C
Severity:
minor
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
null
Description:
Vitamin C is a mandatory cofactor for collagen synthesis, which is fundamental for repairing connective tissues, a primary target for TB-500's action.
Actionable advice:
Ensure adequate Vitamin C intake to provide the necessary building blocks for tissue repair.
Target id:
/class/nsaids
Target name:
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
High-dose or chronic NSAID use can dampen the initial inflammatory signals required for tissue repair, potentially slightly reducing the efficacy of TB-500's healing mechanisms.
Actionable advice:
For acute injuries, consider minimizing NSAID use to allow the full effects of TB-500.
Target id:
/intervention/exercise
Target name:
Exercise
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0.5
Hours after target:
2
Description:
Administering TB-500 around the time of physical activity may help target its systemic regenerative effects to tissues stimulated or stressed by the exercise.
Actionable advice:
For targeted repair, consider injecting within 2 hours after your workout.
Target id:
/biomarker/hs-crp
Target name:
hs-CRP (High-Sensitivity C-Reactive Protein)
Severity:
minor
Interaction type:
assay_interference
Nature:
absolute
Temporal spacing:
null
Description:
TB-500's potent anti-inflammatory effects can lower hs-CRP levels, which should be interpreted as a physiological effect of the intervention, not a baseline reading.
Actionable advice:
Be aware that hs-CRP levels may be lowered due to the peptide's action when interpreting lab results.