Meta Information
ID:tart-cherry-extract
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Tart cherry contains compounds that may inhibit platelet aggregation, potentially increasing the effects of anticoagulant and antiplatelet medications and raising the risk of bleeding.
Actionable advice:
Consult your doctor before using if you take blood-thinning medications or have a bleeding disorder.
Target id:
/condition/bleeding-disorders
Target name:
Bleeding Disorders
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Tart cherry's potential antiplatelet effects may significantly increase the risk of bleeding in individuals with pre-existing bleeding disorders like hemophilia or von Willebrand disease.
Actionable advice:
Avoid tart cherry extract completely if you have a bleeding disorder.
Target id:
/procedure/surgery
Target name:
Upcoming Surgery
Severity:
major
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
336
Hours after target:
null
Description:
Due to its potential to affect blood clotting, tart cherry extract may increase the risk of excessive bleeding during and after surgical procedures.
Actionable advice:
Discontinue use at least 2 weeks before any scheduled surgery.
Target id:
/class/antihypertensives
Target name:
Antihypertensive Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Tart cherry may lower blood pressure, and taking it with antihypertensive drugs could cause an additive effect, potentially leading to excessively low blood pressure (hypotension).
Actionable advice:
Monitor blood pressure closely and consult your doctor if you are taking medication for high blood pressure.
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Tart cherry may lower blood sugar levels, which can have an additive effect with diabetes medications, increasing the risk of hypoglycemia (dangerously low blood sugar).
Actionable advice:
Monitor blood glucose levels carefully and consult your doctor if you are taking any diabetes medications.
Target id:
/class/glucose-lowering-supplements
Target name:
Glucose-Lowering Supplements
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Combining tart cherry with other supplements that lower blood sugar (e.g., berberine, cinnamon) can increase the risk of hypoglycemia (low blood sugar).
Actionable advice:
Use caution and monitor for symptoms of low blood sugar when combining with other glucose-lowering supplements.
Target id:
/condition/diabetes-mellitus
Target name:
Diabetes Mellitus
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Tart cherry can lower blood sugar, which requires careful monitoring for individuals with diabetes to prevent hypoglycemia, especially if they are on medication.
Actionable advice:
If you have diabetes, monitor your blood sugar closely when starting tart cherry and consult your doctor.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
null
Description:
Tart cherry is a natural source of melatonin and tryptophan, which can improve sleep onset and quality by supporting the body's natural sleep-wake cycle.
Actionable advice:
Take your dose approximately 1-2 hours before your intended bedtime for optimal sleep benefits.
Target id:
/class/cns-depressants
Target name:
Sedatives and Sleep Aids
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Tart cherry contains natural melatonin and may have sedative properties, which can be additive with other sleep aids or sedating medications, potentially causing excessive drowsiness.
Actionable advice:
Avoid combining with prescription sedatives unless approved by your doctor; use caution with other sleep supplements.
Target id:
/intervention/exercise
Target name:
Exercise (Post-Workout)
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
null
Hours after target:
2
Description:
The anti-inflammatory and antioxidant compounds in tart cherry help reduce muscle damage and soreness (DOMS) when consumed after strenuous exercise.
Actionable advice:
For muscle recovery, consume tart cherry extract within two hours after completing your workout.
Target id:
/biomarker/uric-acid
Target name:
Uric Acid Levels
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Anthocyanins in tart cherry can increase kidney excretion of uric acid and inhibit xanthine oxidase, an enzyme involved in uric acid production, helping to lower serum levels.
Actionable advice:
Regular use can help maintain lower, healthier uric acid levels, which may be monitored via blood tests.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
The safety of concentrated tart cherry extract supplements during pregnancy has not been established.
Actionable advice:
Avoid using tart cherry extract supplements during pregnancy.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
It is unknown if the concentrated compounds in tart cherry extract are excreted in breast milk or their effects on an infant.
Actionable advice:
Avoid using tart cherry extract supplements while breastfeeding.
Target id:
/class/cyp2c9-substrates
Target name:
Drugs Metabolized by CYP2C9
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Description:
Components in tart cherry may theoretically inhibit the CYP2C9 enzyme, potentially increasing levels of drugs metabolized by this pathway, though this effect is not well-documented in humans.
Actionable advice:
Be aware of this theoretical interaction if taking sensitive CYP2C9 substrate medications like warfarin or certain NSAIDs.
Target id:
/biomarker/hs-crp
Target name:
hs-CRP (High-Sensitivity C-Reactive Protein)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Description:
The potent antioxidant and anti-inflammatory properties of tart cherry polyphenols can help reduce systemic inflammation, which may be reflected by a decrease in hs-CRP levels.
Actionable advice:
Consistent intake may contribute to lower levels of this key inflammatory marker over time.