Pregnenolone is a neurosteroid and the primary precursor to all other steroid hormones, including DHEA, testosterone, estrogens, and cortisol. Its levels decline significantly with age. The sustained-release formulation aims to mimic a more youthful, stable physiological release pattern, potentially supporting cognitive function, memory, and mood without the sharp hormonal spikes of standard formulations.
Verdict
An experimental neurosteroid precursor; proceed with caution and medical supervision.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Moderate
EVIDENCE GRADE
C
MONTHLY COST
$15 - $40
Protocol
- A typical starting dose is 25-50 mg taken once daily, usually in the morning, to mimic natural diurnal rhythms.
- Dosage may be titrated based on bloodwork and individual response, rarely exceeding 100 mg daily for healthspan purposes.
Flags
- Can convert to other hormones like DHEA, testosterone, or estrogen, potentially causing hormonal imbalances.
- Should be avoided by individuals with a history of hormone-sensitive cancers (e.g., breast, prostate).
- May cause side effects such as acne, hair loss, irritability, or anxiety.
- Regular blood testing of downstream hormones (DHEA-S, estradiol, testosterone, cortisol) is highly recommended.
- The sustained-release profile may alter conversion pathways compared to standard formulations.