Meta Information

ID:sustained-release-pregnenolone

Name:Sustained Release Pregnenolone

Schema Version:1.5

Alternate Names

• Pregnenolone SR
• Time-Release Pregnenolone

Active Compound

pregnenolone

Intervention Type

therapeutic_agent

Delivery

Route:

oral

Scope:

• systemic

Regulatory Status

• us:dietary_supplement

Indication

Focus:

healthspan

Description:

Supports cognitive function, mood, and hormonal balance during aging by providing a precursor to other neurosteroids and sex hormones.

Typical Protocol

• A typical starting dose is 25-50 mg taken once daily, usually in the morning, to mimic natural diurnal rhythms.
• Dosage may be titrated based on bloodwork and individual response, rarely exceeding 100 mg daily for healthspan purposes.

Expected Cost Mean

Low Cost:

15

High Cost:

40

Cost Type:

monthly

Description:

Widely available as an over-the-counter supplement; not covered by insurance.

Summary

Pregnenolone is a neurosteroid and the primary precursor to all other steroid hormones, including DHEA, testosterone, estrogens, and cortisol. Its levels decline significantly with age. The sustained-release formulation aims to mimic a more youthful, stable physiological release pattern, potentially supporting cognitive function, memory, and mood without the sharp hormonal spikes of standard formulations.

Purpose

A precursor hormone to support cognitive function and hormonal balance.

Card Summary

A sustained-release neurosteroid precursor intended to support cognitive function and hormonal balance with age.

Drug Class

neurosteroid

Drugs In Class

Empty Array

Impact

Score:

3.5

Justification:

A precursor hormone with unpredictable downstream effects; lacks robust human data for systemic healthspan benefits.

Evidence

Grade:

C

Score:

3

Justification:

Primarily supported by mechanistic reasoning and animal studies; lacks large-scale human healthspan trials.

Safety

Score:

5.5

Justification:

Can unpredictably alter downstream hormone levels (e.g., estrogens, androgens, cortisol), requiring monitoring.

Flags

• Can convert to other hormones like DHEA, testosterone, or estrogen, potentially causing hormonal imbalances.
• Should be avoided by individuals with a history of hormone-sensitive cancers (e.g., breast, prostate).
• May cause side effects such as acne, hair loss, irritability, or anxiety.
• Regular blood testing of downstream hormones (DHEA-S, estradiol, testosterone, cortisol) is highly recommended.
• The sustained-release profile may alter conversion pathways compared to standard formulations.

Verdict

An experimental neurosteroid precursor; proceed with caution and medical supervision.

Created

2026-06-12T17:46:50.076114Z

Ai Model

Gemini 2.5 Pro (High)