Sulforaphane is a potent isothiocyanate compound derived from cruciferous vegetables like broccoli. Its primary mechanism for healthspan is the robust activation of the Nrf2 genetic pathway, which is a master regulator of the body's antioxidant and detoxification systems. By upregulating hundreds of protective genes, sulforaphane helps mitigate cellular damage from oxidative stress and environmental toxins, key drivers of the aging process.
Verdict
A promising Nrf2 activator for cellular defense with good safety.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$20 - $50
Protocol
- Take 20-60 mg of sulforaphane daily, often via stabilized glucoraphanin supplements with myrosinase.
Flags
- Bioavailability varies greatly; supplements with myrosinase enzyme are preferred for glucoraphanin.
- May interact with drugs metabolized by cytochrome P450 enzymes.
- Theoretically may impact thyroid function, especially with low iodine intake.