Meta Information
ID:sulforaphane
Name:Sulforaphane
Schema Version:1.5
Title
Sulforaphane
Alternate Names
- SFN
- Glucoraphanin
- Broccoli Sprout Extract
Intervention Type
therapeutic_agent
Expected Cost Mean
Low Cost:
20
High Cost:
50
Cost Type:
monthly
Description:
Cost for stabilized glucoraphanin or direct sulforaphane supplements.
Summary
Sulforaphane is a potent isothiocyanate compound derived from cruciferous vegetables like broccoli. Its primary mechanism for healthspan is the robust activation of the Nrf2 genetic pathway, which is a master regulator of the body's antioxidant and detoxification systems. By upregulating hundreds of protective genes, sulforaphane helps mitigate cellular damage from oxidative stress and environmental toxins, key drivers of the aging process.
Purpose
Activates Nrf2 pathway to boost antioxidant and detoxification systems.
Card Summary
A potent Nrf2 activator from cruciferous vegetables that enhances cellular detoxification and antioxidant defenses.
Drug Class
Drugs In Class
Empty Array
Impact
Score:
5.5
Justification:
Potent Nrf2 activator with strong effects on detoxification and antioxidant pathways.
Evidence
Grade:
B
Score:
6.5
Justification:
Strong mechanistic and animal data, supported by smaller human trials on biomarkers.
Safety
Score:
2.5
Justification:
Generally recognized as safe (GRAS) with a strong safety profile; mild GI upset possible.
Flags
- Bioavailability varies greatly; supplements with myrosinase enzyme are preferred for glucoraphanin.
- May interact with drugs metabolized by cytochrome P450 enzymes.
- Theoretically may impact thyroid function, especially with low iodine intake.
Verdict
A promising Nrf2 activator for cellular defense with good safety.
Created
2026-04-24T00:12:26.704818Z
Model
Gemini 3.1 Pro (High)
Delivery
Route:
oral
Scope:
- systemic
Indication
Focus:
healthspan
Description:
Sulforaphane is a potent isothiocyanate compound derived from cruciferous vegetables like broccoli. Its primary mechanism for healthspan is the robust activation of the Nrf2 genetic pathway, which is ...
Typical Protocol
- Take 20-60 mg of sulforaphane daily, often via stabilized glucoraphanin supplements with myrosinase.