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Sulbutiamine

Arcalion, Enerion, Bisibutiamine

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Meta Information

ID:sulbutiamine
Name:Sulbutiamine
Schema Version:1.5

Alternate Names

  • Arcalion
  • Enerion
  • Bisibutiamine

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:
20
High Cost:
40
Cost Type:
monthly
Description:
Widely available as an unregulated dietary supplement; not covered by insurance.

Summary

Sulbutiamine is a synthetic derivative of thiamine (vitamin B1) engineered to more easily cross the blood-brain barrier. It aims to increase brain thiamine levels, which may support cholinergic and dopaminergic neurotransmission. Its relevance to healthspan is highly speculative, primarily focused on its potential to alleviate fatigue (asthenia) and support cognitive function, with no direct evidence for extending lifespan or preventing age-related diseases.

Purpose

A synthetic vitamin B1 derivative for fatigue and cognitive support.

Card Summary

A synthetic form of vitamin B1 (thiamine) designed to cross the blood-brain barrier, primarily used for fatigue and cognitive support with no direct longevity evidence.

Drug Class

Drugs In Class

Empty Array

Impact

Score:
2.5
Justification:
No direct evidence for healthspan extension; limited data for fatigue and cognition.

Evidence

Grade:
B
Score:
3.5
Justification:
Limited, small, and often dated human trials primarily focused on fatigue (asthenia).

Safety

Score:
3
Justification:
Generally well-tolerated with mild side effects; long-term safety data is lacking.

Flags

  • Tolerance may develop with continuous use, necessitating cycling.
  • Can cause mild side effects like agitation, headache, or insomnia.
  • Banned for in-competition use by the World Anti-Doping Agency (WADA).
  • Long-term safety profile in healthy individuals is not well-established.

Verdict

Speculative nootropic for fatigue; no proven benefit for healthspan or longevity.

Created

2026-04-27T00:49:33.168569Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:
oral
Scope:
  • systemic

Indication

Focus:
healthspan
Description:
Sulbutiamine is a synthetic derivative of thiamine (vitamin B1) engineered to more easily cross the blood-brain barrier. It aims to increase brain thiamine levels, which may support cholinergic and do...

Typical Protocol

  • Typical use involves 200-600 mg daily, often cycled for several weeks on and off to prevent tolerance.