Meta Information
ID:sulbutiamine
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/dietary/high-fat-meal
Target name:
Meal Containing Fats
Severity:
moderate
Interaction type:
requirement
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Sulbutiamine is a lipophilic (fat-soluble) compound, and its absorption from the gut is significantly enhanced when consumed with dietary fats.
Actionable advice:
Take sulbutiamine with a meal that includes a source of healthy fats like avocado, nuts, or olive oil.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
moderate
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
8
Hours after target:
null
Description:
Sulbutiamine often has stimulating effects on the central nervous system which can interfere with sleep onset, duration, and quality.
Actionable advice:
Take your dose in the morning or early afternoon, at least 8 hours before your planned bedtime.
Target id:
/class/stimulants
Target name:
Stimulant Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Sulbutiamine can exert its own stimulating effects and may potentiate the action of other stimulants, increasing the risk of overstimulation, anxiety, jitteriness, and increased heart rate.
Actionable advice:
Avoid combining with prescription stimulants (e.g., for ADHD) or use with extreme caution under medical supervision.
Target id:
/condition/bipolar-disorder
Target name:
Bipolar Disorder
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The stimulating and mood-elevating properties of sulbutiamine have been documented in case reports to trigger manic or hypomanic episodes in individuals with bipolar disorder.
Actionable advice:
Avoid completely if you have a diagnosis of, or predisposition to, bipolar disorder.
Target id:
/intervention/sulbutiamine-chronic-use
Target name:
Continuous Daily Use of Sulbutiamine
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Continuous daily administration of sulbutiamine frequently leads to rapid pharmacological tolerance, where its noticeable psychoactive effects (stimulation, mood enhancement) diminish or disappear.
Actionable advice:
To maintain effectiveness, cycle sulbutiamine by using it only on an as-needed basis or a few times per week.
Target id:
/circadian/wake
Target name:
Waking Up
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
null
Hours after target:
4
Description:
Taking sulbutiamine in the morning aligns its energizing effects with the body's natural circadian rhythm for wakefulness, potentially improving focus and combating fatigue during the day.
Actionable advice:
Take sulbutiamine within the first few hours of waking for optimal daytime effects.
Target id:
/class/dopaminergic-agents
Target name:
Dopaminergic Medications
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Sulbutiamine may increase the density of dopamine D1 receptors in the brain, which could theoretically alter the effects of medications that act on the dopamine system (e.g., L-DOPA, dopamine agonists).
Actionable advice:
Use with caution and consult a physician if combining with dopaminergic medications.
Target id:
/class/cholinesterase-inhibitors
Target name:
Cholinesterase Inhibitors
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Some evidence suggests sulbutiamine may enhance cholinergic activity. Combining it with cholinesterase inhibitors (e.g., Huperzine A, galantamine) could theoretically increase the risk of cholinergic side effects like headaches or digestive upset.
Actionable advice:
Monitor for side effects if combining with supplements or drugs that inhibit cholinesterase.
Target id:
/class/diuretics
Target name:
Diuretics (Water Pills)
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Diuretics, particularly loop diuretics, increase the urinary excretion of thiamine (Vitamin B1). Chronic use may increase the body's overall thiamine requirement, potentially impacting the baseline upon which sulbutiamine acts.
Actionable advice:
If using diuretics long-term, discuss your overall thiamine status with your doctor.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The safety and effects of sulbutiamine on fetal development have not been studied in humans.
Actionable advice:
Avoid completely during pregnancy due to a lack of safety data.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is not known whether sulbutiamine or its metabolites are excreted into human breast milk or what effects they might have on a nursing infant.
Actionable advice:
Avoid completely while breastfeeding due to a lack of safety data.