Spermidine is a naturally occurring polyamine essential for cellular function whose levels decline with age. Its primary healthspan-related mechanism is the potent induction of autophagy, the body's cellular recycling system that clears out damaged components. Supplementation aims to restore youthful levels of autophagy, potentially mitigating age-related cellular damage and supporting cardiovascular and cognitive health.
Verdict
A promising, safe autophagy-inducer with developing human evidence for healthspan.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$30 - $70
Protocol
- Typical daily doses for healthspan range from 1 mg to 10 mg, often sourced from wheat germ extract.
Flags
- Supplements are often derived from wheat germ, a potential concern for gluten-sensitive individuals.
- High doses may cause mild gastrointestinal upset in some individuals.
- Consult a physician if pregnant, nursing, or taking other medications.