Meta Information
ID:spermidine
Name:
Schema Version:AIM-2.0
Created
2026-05-10T18:33:02.330114Z
Model
Gemini 3.1 Pro (High)
Interactions
Target id:
/intervention/methionine-restriction
Target name:
Methionine Restriction
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
This diet reduces the body's spermidine precursor; supplementation directly compensates for this effect.
Actionable advice:
May be particularly beneficial.
Target id:
/intervention/dasatinib-quercetin
Target name:
Dasatinib and Quercetin
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Spermidine's autophagy effects may complement the senolytic action of this combination for cellular rejuvenation.
Actionable advice:
Use under medical supervision.
Target id:
/intervention/intermittent-fasting
Target name:
Intermittent Fasting
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Spermidine induces autophagy, a key process also activated by fasting, potentially amplifying cellular renewal.
Actionable advice:
May enhance fasting-related benefits.
Target id:
/intervention/trehalose
Target name:
Trehalose
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Both are potent inducers of cellular autophagy, potentially leading to a strong synergistic effect.
Actionable advice:
No specific action required.
Target id:
/intervention/urolithin-a
Target name:
Urolithin A
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Spermidine (autophagy) and Urolithin A (mitophagy) offer complementary cellular cleanup mechanisms for enhanced benefit.
Actionable advice:
No specific action required.
Target id:
/intervention/fisetin
Target name:
Fisetin
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Both promote autophagy and have senolytic properties, potentially enhancing cellular health and rejuvenation.
Actionable advice:
No specific action required.
Target id:
/intervention/mtor-inhibitors
Target name:
mTOR Inhibitors
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Both substances promote cellular autophagy, potentially enhancing cellular cleanup and anti-aging effects.
Actionable advice:
Discuss combination with a specialist.
Target id:
/intervention/resveratrol
Target name:
Resveratrol
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Both compounds may activate autophagy, potentially leading to enhanced cellular health and longevity benefits.
Actionable advice:
No specific action required.
Target id:
/intervention/egcg-green-tea
Target name:
Egcg
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Both compounds are known to induce autophagy, potentially leading to enhanced cellular health benefits.
Actionable advice:
No specific action required.
Target id:
/intervention/lithium
Target name:
Lithium Orotate
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Both lithium and spermidine are known to induce cellular autophagy, potentially enhancing cellular cleanup.
Actionable advice:
No specific action required.
Target id:
/intervention/metformin
Target name:
Metformin
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Both may activate cellular autophagy pathways, potentially enhancing cellular renewal and metabolic benefits.
Actionable advice:
Monitor blood glucose if combining.
Target id:
/intervention/ace-inhibitors
Target name:
ACE Inhibitors
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Description:
Spermidine may also lower blood pressure, potentially increasing the risk of hypotension when combined.
Actionable advice:
Monitor blood pressure closely.
Target id:
/intervention/amlodipine
Target name:
Amlodipine
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Description:
Spermidine may also lower blood pressure, potentially increasing the risk of hypotension when combined.
Actionable advice:
Monitor blood pressure closely.
Target id:
/intervention/angiotensin-receptor-blockers
Target name:
Angiotensin Receptor Blockers
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Description:
Spermidine may also lower blood pressure, potentially increasing the risk of hypotension when combined.
Actionable advice:
Monitor blood pressure closely.
Target id:
/intervention/metoprolol
Target name:
Metoprolol
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Description:
Spermidine may also lower blood pressure, potentially increasing the risk of hypotension when combined.
Actionable advice:
Monitor blood pressure closely.
Target id:
/intervention/nebivolol
Target name:
Nebivolol
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Description:
Spermidine may also lower blood pressure, potentially increasing the risk of hypotension when combined.
Actionable advice:
Monitor blood pressure closely.
Target id:
/intervention/statins
Target name:
Statins
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Description:
Statins may increase cellular uptake of polyamines, potentially enhancing the effects of spermidine.
Actionable advice:
No specific action required.