Poly-L-lactic acid is a biocompatible, biodegradable synthetic polymer injected into the deep dermis to stimulate the body's own collagen production. Its healthspan relevance is primarily cosmetic, addressing age-related volume loss and skin laxity, which can positively impact psychosocial well-being but does not directly modulate systemic aging pathways.
Verdict
Effective for cosmetic skin aging, but offers no direct systemic healthspan benefit.
HEALTHSPAN IMPACT
Negligible
RISK LEVEL
Moderate
EVIDENCE GRADE
A
MONTHLY COST
$2000 - $5000
Protocol
- An initial series of 2-3 treatments is typically performed 4-6 weeks apart.
- Maintenance treatments are commonly administered every 1-2 years to sustain results.
Flags
- Risk of nodules or granulomas, particularly with improper injection technique or dilution.
- Not recommended for individuals with autoimmune diseases or active skin inflammation.
- Results are gradual, appearing over several months, and are not permanent.
- Efficacy and safety are highly dependent on practitioner skill and experience.