S-adenosylmethionine (SAM-e) is a naturally occurring compound that serves as a universal methyl donor in hundreds of metabolic reactions. Its healthspan relevance is linked to its critical role in maintaining epigenetic patterns, synthesizing the master antioxidant glutathione, and producing key neurotransmitters, all of which can be compromised during aging.
Verdict
A targeted tool for mood and joint support, not a core longevity agent.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$20 - $45
Protocol
- Take 200-800 mg daily on an empty stomach for methylation support, often with B-vitamin cofactors.
Flags
- Should not be combined with SSRIs or other serotonergic drugs due to risk of serotonin syndrome.
- May induce mania in individuals with bipolar disorder.
- May increase homocysteine; co-supplementation with B-vitamins (B6, B12, folate) is often recommended.
- Can cause mild gastrointestinal upset or anxiety in sensitive individuals.