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SAM-e

S-adenosylmethionine, Ademetionine

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Meta Information

ID:sam-e
Name:SAM-e
Schema Version:1.5

Alternate Names

  • S-adenosylmethionine
  • Ademetionine

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:
20
High Cost:
45
Cost Type:
monthly
Description:
Cost for a 30-day supply of standard dose enteric-coated tablets.

Summary

S-adenosylmethionine (SAM-e) is a naturally occurring compound that serves as a universal methyl donor in hundreds of metabolic reactions. Its healthspan relevance is linked to its critical role in maintaining epigenetic patterns, synthesizing the master antioxidant glutathione, and producing key neurotransmitters, all of which can be compromised during aging.

Purpose

A universal methyl donor supporting mood, joints, and epigenetic maintenance.

Card Summary

A key methyl donor involved in hundreds of metabolic reactions, SAM-e supports mood, joint health, and liver function by maintaining cellular methylation and antioxidant status.

Drug Class

Drugs In Class

Empty Array

Impact

Score:
4.5
Justification:
Supports critical methylation pathways but lacks direct evidence for extending human healthspan.

Evidence

Grade:
B
Score:
6.5
Justification:
Strong human RCT data for depression and osteoarthritis, but not for longevity.

Safety

Score:
3.8
Justification:
Generally well-tolerated but can cause mild side effects and interact with antidepressants.

Flags

  • Should not be combined with SSRIs or other serotonergic drugs due to risk of serotonin syndrome.
  • May induce mania in individuals with bipolar disorder.
  • May increase homocysteine; co-supplementation with B-vitamins (B6, B12, folate) is often recommended.
  • Can cause mild gastrointestinal upset or anxiety in sensitive individuals.

Verdict

A targeted tool for mood and joint support, not a core longevity agent.

Created

2026-04-26T18:17:13.562140Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:
oral
Scope:
  • systemic

Indication

Focus:
healthspan
Description:
S-adenosylmethionine (SAM-e) is a naturally occurring compound that serves as a universal methyl donor in hundreds of metabolic reactions. Its healthspan relevance is linked to its critical role in ma...

Typical Protocol

  • Take 200-800 mg daily on an empty stomach for methylation support, often with B-vitamin cofactors.