Saccharomyces boulardii is a non-pathogenic, transient yeast used as a probiotic. It supports gut health by competing with pathogens, strengthening the intestinal barrier, and modulating local immune responses. For healthspan, its primary value lies in maintaining gut microbiome resilience against stressors like antibiotics or travel, which helps mitigate systemic low-grade inflammation originating from gut dysbiosis.
Verdict
A well-evidenced tool for maintaining gut resilience, especially during antibiotic therapy.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
A
MONTHLY COST
$15 - $40
Protocol
- Take 5-10 billion CFUs (Colony Forming Units), typically 250-500 mg, once or twice daily.
- Often used prophylactically during and for a short period after antibiotic courses.
Flags
- Risk of systemic fungemia in severely immunocompromised or critically ill patients, especially those with central venous catheters.
- Should not be taken concurrently with systemic antifungal medications as they will negate its effect.
- As a live organism, potency can be affected by improper storage (heat and moisture).