Meta Information

ID:saccharomyces-boulardii

Name:Saccharomyces boulardii

Schema Version:1.5

Alternate Names

• S. boulardii
• Florastor

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

15

High Cost:

40

Cost Type:

monthly

Description:

Widely available over-the-counter probiotic supplement; not covered by insurance.

Summary

Saccharomyces boulardii is a non-pathogenic, transient yeast used as a probiotic. It supports gut health by competing with pathogens, strengthening the intestinal barrier, and modulating local immune responses. For healthspan, its primary value lies in maintaining gut microbiome resilience against stressors like antibiotics or travel, which helps mitigate systemic low-grade inflammation originating from gut dysbiosis.

Purpose

A probiotic yeast that supports gut barrier integrity and immune function.

Card Summary

A unique probiotic yeast that helps maintain gut integrity and balance, especially during antibiotic use.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Targets gut health, a key system, but lacks direct longevity evidence.

Evidence

Grade:

A

Score:

8.5

Justification:

Multiple high-quality human RCTs confirm efficacy for specific gut-related conditions.

Safety

Score:

2.5

Justification:

Generally Recognized As Safe (GRAS) with rare risks in severely immunocompromised individuals.

Flags

• Risk of systemic fungemia in severely immunocompromised or critically ill patients, especially those with central venous catheters.
• Should not be taken concurrently with systemic antifungal medications as they will negate its effect.
• As a live organism, potency can be affected by improper storage (heat and moisture).

Verdict

A well-evidenced tool for maintaining gut resilience, especially during antibiotic therapy.

Created

2026-04-26T18:11:04.952144Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

disease_treatment

Description:

Saccharomyces boulardii is a non-pathogenic, transient yeast used as a probiotic. It supports gut health by competing with pathogens, strengthening the intestinal barrier, and modulating local immune ...

Typical Protocol

• Take 5-10 billion CFUs (Colony Forming Units), typically 250-500 mg, once or twice daily.
• Often used prophylactically during and for a short period after antibiotic courses.