Meta Information
ID:rhodiola-rosea
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/maois
Target name:
Monoamine Oxidase Inhibitors (MAOIs)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Rhodiola has mild MAO-inhibiting properties which can add to the effects of MAOI drugs, potentially causing a hypertensive crisis or serotonin syndrome.
Actionable advice:
Avoid taking Rhodiola with MAOI medications completely.
Target id:
/condition/bipolar-disorder
Target name:
Bipolar Disorder
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The stimulating and mood-elevating effects of Rhodiola can potentially trigger manic or hypomanic episodes in individuals with bipolar disorder.
Actionable advice:
Avoid Rhodiola completely if you have a diagnosis of bipolar disorder.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
There is insufficient safety data to establish the safety of Rhodiola rosea during pregnancy.
Actionable advice:
Do not use Rhodiola if you are pregnant.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is unknown if the active compounds in Rhodiola are excreted in breast milk or what their effects on a nursing infant might be.
Actionable advice:
Do not use Rhodiola while breastfeeding.
Target id:
/class/serotonergic-agents
Target name:
Serotonergic Medications (SSRIs, SNRIs, TCAs, Triptans)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Rhodiola's mild MAO-inhibiting effect can increase serotonin levels, which may heighten the risk of serotonin syndrome when combined with other serotonergic drugs.
Actionable advice:
Use with caution and under medical supervision when combined with any antidepressant or serotonergic medication.
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Rhodiola may lower blood glucose levels, potentially enhancing the effect of diabetes medications and increasing the risk of hypoglycemia (low blood sugar).
Actionable advice:
Monitor blood glucose closely and consult your doctor before using Rhodiola with diabetes medications.
Target id:
/class/antihypertensives
Target name:
Antihypertensive Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Rhodiola may have a mild blood pressure-lowering effect, which could be additive with antihypertensive drugs, potentially causing hypotension (low blood pressure).
Actionable advice:
Monitor your blood pressure regularly if combining Rhodiola with blood pressure-lowering medications.
Target id:
/class/cyp3a4-substrates
Target name:
CYP3A4 Substrates
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Rhodiola can inhibit the CYP3A4 enzyme, which may slow the metabolism of many common medications, potentially increasing their concentration and risk of side effects.
Actionable advice:
Consult a pharmacist or doctor to check for interactions if you take any prescription medications metabolized by CYP3A4.
Target id:
/class/cyp2c9-substrates
Target name:
Drugs Metabolized by CYP2C9
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Rhodiola may inhibit the CYP2C9 enzyme, potentially increasing levels of drugs like warfarin, phenytoin, and some NSAIDs, which raises the risk of adverse effects.
Actionable advice:
Use with extreme caution and medical guidance if you take medications metabolized by CYP2C9, especially warfarin.
Target id:
/class/stimulants
Target name:
Stimulant Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Combining the stimulating effects of Rhodiola with prescription stimulants (e.g., for ADHD) can lead to overstimulation, anxiety, jitteriness, or insomnia.
Actionable advice:
Avoid or use with extreme caution under medical supervision when taking with other stimulant medications.
Target id:
/intervention/caffeine
Target name:
Caffeine
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The stimulating properties of Rhodiola can have an additive effect with caffeine, potentially causing increased heart rate, anxiety, or jitteriness.
Actionable advice:
Reduce or eliminate caffeine intake when starting Rhodiola to assess your tolerance.
Target id:
/class/immunosuppressants
Target name:
Immunosuppressant Medications
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
As an immune-modulating adaptogen, Rhodiola could theoretically interfere with or counteract the effects of immunosuppressant drugs.
Actionable advice:
Avoid Rhodiola if you are taking immunosuppressant drugs for an autoimmune condition or organ transplant.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
moderate
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
8
Hours after target:
null
Description:
The stimulating properties of Rhodiola, particularly at lower doses, can interfere with sleep onset and quality if taken too close to bedtime.
Actionable advice:
Take Rhodiola in the morning or early afternoon, at least 8 hours before your planned bedtime.
Target id:
/circadian/wake
Target name:
Waking Up
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
null
Hours after target:
1
Description:
Taking Rhodiola in the morning aligns its energizing and cortisol-modulating effects with the body's natural circadian rhythm, enhancing focus and resilience to stress.
Actionable advice:
Take your daily dose of Rhodiola within an hour of waking up for optimal effect.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
There is a theoretical risk that Rhodiola may have mild antiplatelet effects, which could slightly increase the risk of bleeding when combined with blood-thinning medications.
Actionable advice:
Use with caution and inform your healthcare provider if you are taking any blood-thinning medications.
Target id:
/class/glucose-lowering-supplements
Target name:
Glucose-Lowering Supplements
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Combining Rhodiola with other supplements that lower blood sugar, such as berberine or cinnamon, can have an additive effect and increase the risk of hypoglycemia.
Actionable advice:
Be cautious and monitor for symptoms of low blood sugar when combining with other glucose-lowering supplements.
Target id:
/class/tyramine-rich-foods
Target name:
Tyramine-Rich Foods
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Due to its weak MAO-inhibiting properties, there is a theoretical risk that Rhodiola could reduce the breakdown of tyramine from aged foods, potentially affecting blood pressure.
Actionable advice:
Be mindful of high-tyramine foods like aged cheeses and cured meats, though a significant interaction is unlikely.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
0.5
Hours after target:
2
Description:
Taking Rhodiola on an empty stomach is thought to improve the absorption and bioavailability of its active compounds, leading to a more pronounced effect.
Actionable advice:
For best results, take Rhodiola at least 30 minutes before or 2 hours after eating a meal.