Resveratrol is a polyphenol that activates sirtuins, particularly SIRT1, which are key regulators of cellular health and aging. The liposomal formulation encapsulates resveratrol in lipid spheres, significantly enhancing its poor natural bioavailability and allowing for more effective delivery to cells. This improved absorption aims to more reliably mimic the cellular benefits observed in preclinical studies, such as improved mitochondrial function and reduced inflammation.
Verdict
A bioavailability-enhanced supplement with promising theory but currently lacking strong human evidence.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$25 - $60
Protocol
- Typical daily doses range from 150 mg to 500 mg, taken once daily.
- Often taken with a source of fat, like olive oil or yogurt, to further enhance absorption.
Flags
- May interact with blood thinners like warfarin, increasing bleeding risk.
- Can inhibit cytochrome P450 enzymes, potentially altering the metabolism of various medications.
- High doses may cause gastrointestinal side effects such as nausea or diarrhea.
- The long-term effects of sustained sirtuin activation in humans are not fully understood.