Rapamycin is a drug historically used to suppress the immune system after organ transplants and to slow abnormal cell growth in certain diseases. It achieves these effects by inhibiting a key cellular pathway called mTOR, which acts as a master regulator of cell growth and metabolism. Based on this same mechanism, researchers are now investigating its off-label use for healthspan optimization, as dampening the mTOR pathway may mimic the effects of caloric restriction and promote cellular maintenance processes that slow age-related decline.
Verdict
A top anti-aging candidate, but requires careful medical supervision due to risks.
HEALTHSPAN IMPACT
High Value
RISK LEVEL
High
EVIDENCE GRADE
B
MONTHLY COST
$40 - $200
Protocol
- A common protocol involves 5-7 mg taken once weekly.
- Some protocols include a 'washout' period of several weeks after 8-12 weeks of use.
Flags
- Can cause immunosuppression, increasing risk of infections.
- May negatively impact glucose metabolism and lipid profiles.
- Common side effects include mouth sores (stomatitis) and impaired wound healing.
- Interacts with many common drugs and grapefruit juice via the CYP3A4 enzyme.
- Long-term safety of intermittent dosing for healthspan is not yet established in humans.