Meta Information
ID:rapamycin
Name:
Schema Version:AIM-2.0
Created
2026-05-10T18:29:25.340685Z
Model
Gemini 3.1 Pro (High)
Interactions
Target id:
/intervention/everolimus
Target name:
Everolimus
Severity:
major
Interaction type:
contraindicated
Nature:
absolute
Description:
Both drugs are mTOR inhibitors; using them together causes excessive toxicity and is irrational.
Actionable advice:
Do not use together; they are alternatives.
Target id:
/intervention/mtor-inhibitors
Target name:
mTOR Inhibitors
Severity:
major
Interaction type:
contraindicated
Nature:
absolute
Description:
Combining mTOR inhibitors is redundant and leads to excessive toxicity and side effects.
Actionable advice:
Do not combine with other mTOR inhibitors.
Target id:
/intervention/dronedarone
Target name:
Dronedarone
Severity:
major
Interaction type:
contraindicated
Nature:
absolute
Description:
Dronedarone strongly increases rapamycin levels, leading to a high risk of severe toxicity.
Actionable advice:
Combination is contraindicated; do not use together.
Target id:
/class/cyp3a4-strong-inhibitors
Target name:
Strong CYP3A4 Inhibitors
Severity:
major
Interaction type:
contraindicated
Nature:
absolute
Description:
These drugs block rapamycin breakdown, leading to dangerously high levels and severe toxicity.
Actionable advice:
Combination is generally contraindicated.
Target id:
/class/live-vaccines
Target name:
Live Attenuated Vaccines
Severity:
major
Interaction type:
contraindicated
Nature:
absolute
Description:
Rapamycin weakens the immune system, risking a full-blown infection from a live vaccine.
Actionable advice:
Avoid live vaccines while on rapamycin.
Target id:
/intervention/dasatinib
Target name:
Dasatinib
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Both drugs interfere with each other's metabolism, increasing levels and risk of toxicity.
Actionable advice:
Avoid combination or adjust doses carefully.
Target id:
/dietary/grapefruit-pomelo
Target name:
Grapefruit, Pomelo, and Seville Oranges
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Grapefruit strongly inhibits an enzyme that breaks down rapamycin, dangerously increasing its levels.
Actionable advice:
Strictly avoid grapefruit products.
Target id:
/class/p-glycoprotein-inducers
Target name:
P-glycoprotein Inducers
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
These drugs increase rapamycin removal from the body, severely reducing its effectiveness.
Actionable advice:
Avoid combination; may cause treatment failure.
Target id:
/intervention/saint-johns-wort
Target name:
Saint John's Wort
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
St. John's Wort significantly speeds up rapamycin breakdown, greatly reducing its effectiveness.
Actionable advice:
Avoid combination; may cause treatment failure.
Target id:
/class/cyp3a4-moderate-inhibitors
Target name:
Moderate CYP3A4 Inhibitors
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
These drugs slow rapamycin breakdown, significantly increasing blood levels and risk of toxicity.
Actionable advice:
Requires significant rapamycin dose reduction.
Target id:
/class/immunosuppressants
Target name:
Calcineurin Inhibitors
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Additive effects increase the risk of over-immunosuppression, leading to serious infections.
Actionable advice:
Requires careful monitoring by a specialist.
Target id:
/intervention/cbd
Target name:
CBD
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
CBD significantly increases rapamycin blood levels, raising the risk of serious toxicity.
Actionable advice:
Requires significant rapamycin dose reduction.
Target id:
/class/p-glycoprotein-inhibitors
Target name:
P-glycoprotein Inhibitors
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
These drugs block rapamycin removal, increasing its absorption and blood levels.
Actionable advice:
Requires rapamycin dose reduction and monitoring.
Target id:
/intervention/amiodarone
Target name:
Amiodarone
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Amiodarone increases rapamycin levels in the blood, raising the risk of toxicity.
Actionable advice:
Requires rapamycin dose reduction and monitoring.
Target id:
/intervention/statins
Target name:
Statins
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Co-administration increases the risk of muscle pain, weakness, and severe muscle damage (rhabdomyolysis).
Actionable advice:
Monitor for muscle symptoms; consider statin dose.
Target id:
/dietary/high-fat-meal
Target name:
High-Fat Meal
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
High-fat meals significantly and unpredictably alter rapamycin absorption, affecting dose consistency and safety.
Actionable advice:
Take consistently with or without food.
Target id:
/class/nephrotoxic-agents
Target name:
Nephrotoxic Agents (NSAIDs, ACEi, ARBs)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Combining with other drugs harmful to kidneys increases the risk of kidney damage.
Actionable advice:
Monitor kidney function closely.
Target id:
/intervention/ace-inhibitors
Target name:
ACE Inhibitors
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Increased risk of angioedema, a serious swelling reaction, when taken together.
Actionable advice:
Monitor for swelling of face, lips, tongue.
Target id:
/intervention/berberine
Target name:
Berberine
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Berberine can increase rapamycin blood levels, raising the risk of side effects.
Actionable advice:
Consider rapamycin dose reduction and monitoring.
Target id:
/intervention/angiotensin-receptor-blockers
Target name:
Angiotensin Receptor Blockers
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Increased risk of angioedema, a serious swelling reaction, when taken together.
Actionable advice:
Monitor for swelling of face, lips, tongue.
Target id:
/intervention/curcumin-and-piperine
Target name:
Curcumin and Piperine
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Piperine increases rapamycin absorption, raising blood levels and side effect risk.
Actionable advice:
Consider rapamycin dose reduction.
Target id:
/intervention/piperine
Target name:
Piperine
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Piperine increases rapamycin absorption, raising blood levels and side effect risk.
Actionable advice:
Consider rapamycin dose reduction.
Target id:
/intervention/quercetin
Target name:
Quercetin
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Quercetin can increase rapamycin blood levels, raising the risk of side effects.
Actionable advice:
Consider rapamycin dose reduction and monitoring.
Target id:
/intervention/milk-thistle
Target name:
Milk Thistle (Silymarin)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Milk thistle may increase rapamycin blood levels, potentially increasing its side effects.
Actionable advice:
Use with caution and monitor for side effects.
Target id:
/intervention/digoxin
Target name:
Digoxin
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Rapamycin may slightly increase digoxin levels, potentially increasing its side effects.
Actionable advice:
Monitor digoxin levels if used together.
Target id:
/intervention/potassium
Target name:
Potassium
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Rapamycin can increase potassium levels; combining with supplements may lead to hyperkalemia.
Actionable advice:
Monitor potassium levels if combining.
Target id:
/intervention/resveratrol
Target name:
Resveratrol
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
Resveratrol may increase rapamycin blood levels, potentially increasing its side effects.
Actionable advice:
Use with caution and monitor for side effects.