Raloxifene is a Selective Estrogen Receptor Modulator (SERM) that acts as an estrogen agonist in bone tissue and an antagonist in breast and uterine tissue. For healthspan, it is primarily used by postmenopausal women to prevent and treat osteoporosis, thereby reducing fracture risk, and to lower the risk of invasive breast cancer. It provides some of estrogen's protective benefits without stimulating potentially harmful growth in other tissues.
Verdict
Proven bone and breast protection for postmenopausal women with notable risks.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Moderate
EVIDENCE GRADE
A
MONTHLY COST
$15 - $40
Protocol
- Take one 60 mg tablet orally once per day, with or without food.
Flags
- Prescription required; primarily indicated for postmenopausal women.
- Increases risk of venous thromboembolism (blood clots) and fatal stroke.
- Common side effects include hot flashes and leg cramps.
- Should not be used in women with a history of VTE.
- Interacts with warfarin and other highly protein-bound drugs.