Meta Information

ID:raloxifene

Name:Raloxifene (SERMs)

Schema Version:1.5

Alternate Names

• Evista

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

15

High Cost:

40

Cost Type:

monthly

Description:

Generic prescription cost; often covered by insurance for approved indications.

Summary

Raloxifene is a Selective Estrogen Receptor Modulator (SERM) that acts as an estrogen agonist in bone tissue and an antagonist in breast and uterine tissue. For healthspan, it is primarily used by postmenopausal women to prevent and treat osteoporosis, thereby reducing fracture risk, and to lower the risk of invasive breast cancer. It provides some of estrogen's protective benefits without stimulating potentially harmful growth in other tissues.

Purpose

Mimics estrogen's bone benefits, reduces breast cancer risk.

Card Summary

A Selective Estrogen Receptor Modulator (SERM) that protects bone density and reduces invasive breast cancer risk in postmenopausal women.

Drug Class

serms

Drugs In Class

Empty Array

Impact

Score:

5.5

Justification:

Strong, targeted benefit for bone and breast health in postmenopausal women.

Evidence

Grade:

A

Score:

9.5

Justification:

Multiple large-scale, long-term human RCTs and meta-analyses confirm efficacy.

Safety

Score:

5.8

Justification:

Increased risk of blood clots (VTE) and potential stroke risk.

Flags

• Prescription required; primarily indicated for postmenopausal women.
• Increases risk of venous thromboembolism (blood clots) and fatal stroke.
• Common side effects include hot flashes and leg cramps.
• Should not be used in women with a history of VTE.
• Interacts with warfarin and other highly protein-bound drugs.

Verdict

Proven bone and breast protection for postmenopausal women with notable risks.

Created

2026-04-26T18:30:59.404491Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Raloxifene is a Selective Estrogen Receptor Modulator (SERM) that acts as an estrogen agonist in bone tissue and an antagonist in breast and uterine tissue. For healthspan, it is primarily used by pos...

Typical Protocol

• Take one 60 mg tablet orally once per day, with or without food.