Meta Information

ID:quercetin-liposomal

Name:Liposomal Quercetin

Schema Version:1.5

Alternate Names

• Liposome-encapsulated quercetin

Active Compound

quercetin

Intervention Type

therapeutic_agent

Delivery

Route:

oral

Scope:

• systemic

Regulatory Status

• us:dietary_supplement
• eu:food_supplement

Indication

Focus:

healthspan

Description:

Targeting cellular senescence and systemic inflammation to support metabolic health and healthy aging.

Typical Protocol

• Typical daily doses range from 250 mg to 500 mg, taken with a meal to enhance absorption.
• Due to higher bioavailability, liposomal doses are often lower than standard quercetin protocols (which can exceed 1000 mg).

Expected Cost Mean

Low Cost:

25

High Cost:

50

Cost Type:

monthly

Description:

Monthly cost for a daily supplement, not typically covered by insurance.

Summary

Quercetin is a flavonoid with potent antioxidant, anti-inflammatory, and potential senolytic properties, meaning it may help clear senescent 'zombie' cells. The liposomal formulation encapsulates quercetin in a lipid sphere, dramatically increasing its poor natural bioavailability, allowing for more effective delivery to cells throughout the body.

Purpose

A bioavailable flavonoid to reduce inflammation and cellular senescence.

Card Summary

A highly bioavailable form of the flavonoid quercetin, used to combat inflammation and cellular senescence.

Drug Class

flavonoid

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Targets key aging pathways like senescence and inflammation, but human healthspan data is limited.

Evidence

Grade:

B

Score:

5.5

Justification:

Human trials show benefits for inflammation/metabolism; senolytic effects primarily from animal studies.

Safety

Score:

3

Justification:

Generally recognized as safe (GRAS) with a good safety profile at typical doses.

Flags

• May interact with antibiotics (quinolones), blood thinners (e.g., warfarin), and cyclosporine.
• Very high doses may potentially lead to kidney damage, though this is rare.
• Liposomal formulations significantly alter pharmacokinetics compared to standard quercetin.
• Quality and dosage can vary significantly between unregulated supplement brands.

Verdict

A promising, bioavailable supplement for inflammation, but direct human senolytic evidence is pending.

Created

2026-06-12T17:47:07.012586Z

Ai Model

Gemini 2.5 Pro (High)