Progesterone is a steroid hormone essential for female reproductive health. In the context of healthspan, it is primarily used in post-menopausal hormone replacement therapy (HRT) to oppose estrogen's proliferative effect on the uterine lining, significantly reducing cancer risk. Its metabolite, allopregnanolone, also acts on GABA-A receptors in the brain, promoting calming effects and improving sleep quality, which are foundational for healthy aging.
Verdict
Essential for safe HRT in women; offers sleep and mood benefits.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Moderate
EVIDENCE GRADE
B
MONTHLY COST
$20 - $50
Protocol
- 100-200 mg of oral micronized progesterone taken nightly, often cyclically for 12-14 days per month.
Flags
- Essential when taking estrogen therapy in women with a uterus to prevent endometrial cancer.
- Bioidentical progesterone has a different risk profile than synthetic progestins.
- Commonly causes drowsiness and is best taken at bedtime.
- Contraindicated in history of certain cancers, liver disease, or thromboembolic events.
- Dosage and administration route significantly alter its metabolic effects.