Meta Information

ID:progesterone

Name:Progesterone

Schema Version:1.5

Title

Progesterone

Alternate Names

• P4
• Bioidentical Progesterone
• Prometrium

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

20

High Cost:

50

Cost Type:

monthly

Description:

Monthly cost for generic oral micronized progesterone prescription.

Summary

Progesterone is a steroid hormone essential for female reproductive health. In the context of healthspan, it is primarily used in post-menopausal hormone replacement therapy (HRT) to oppose estrogen's proliferative effect on the uterine lining, significantly reducing cancer risk. Its metabolite, allopregnanolone, also acts on GABA-A receptors in the brain, promoting calming effects and improving sleep quality, which are foundational for healthy aging.

Purpose

A steroid hormone used to balance estrogen and improve sleep.

Card Summary

A key female steroid hormone, primarily used in post-menopausal HRT to protect the uterus from estrogen-driven growth. It also promotes sleep and may have neuroprotective effects.

Drug Class

progestins

Drugs In Class

Empty Array

Impact

Score:

5.5

Justification:

Crucial for safe estrogen therapy in women; provides direct sleep and neuroprotective benefits.

Evidence

Grade:

B

Score:

7.5

Justification:

Strong evidence for endometrial protection; moderate evidence for sleep and neuroprotection benefits.

Safety

Score:

5

Justification:

Requires prescription and monitoring; side effects are common but generally manageable.

Flags

• Essential when taking estrogen therapy in women with a uterus to prevent endometrial cancer.
• Bioidentical progesterone has a different risk profile than synthetic progestins.
• Commonly causes drowsiness and is best taken at bedtime.
• Contraindicated in history of certain cancers, liver disease, or thromboembolic events.
• Dosage and administration route significantly alter its metabolic effects.

Verdict

Essential for safe HRT in women; offers sleep and mood benefits.

Created

2026-04-23T23:50:09.915928Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Progesterone is a steroid hormone essential for female reproductive health. In the context of healthspan, it is primarily used in post-menopausal hormone replacement therapy (HRT) to oppose estrogen's...

Typical Protocol

• 100-200 mg of oral micronized progesterone taken nightly, often cyclically for 12-14 days per month.