Polynucleotides are purified DNA fragments, typically derived from salmon, that are injected into the skin. They act as signaling molecules to stimulate fibroblasts, promote collagen and elastin synthesis, improve hydration, and reduce inflammation, leading to enhanced skin quality and tissue regeneration. Their relevance to healthspan is currently confined to improving the structural integrity and appearance of the skin, a key organ.
Verdict
A promising aesthetic tool for skin rejuvenation, not a systemic intervention.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$1500 - $3000
Protocol
- A course of 2-3 injection sessions spaced 2-4 weeks apart, repeated annually.
Flags
- Primarily an aesthetic treatment; systemic healthspan benefits are speculative.
- Contraindicated for individuals with fish or salmon allergies.
- Requires a skilled practitioner for safe and effective administration.
- Results are temporary and require maintenance treatments.