Meta Information

ID:polynucleotides

Name:Polynucleotides

Schema Version:1.5

Alternate Names

• PN
• PDRN
• Polydeoxyribonucleotide

Intervention Type

procedure

Expected Cost Mean

Low Cost:

1500

High Cost:

3000

Cost Type:

procedure

Description:

Cost for a full treatment course; not covered by insurance.

Summary

Polynucleotides are purified DNA fragments, typically derived from salmon, that are injected into the skin. They act as signaling molecules to stimulate fibroblasts, promote collagen and elastin synthesis, improve hydration, and reduce inflammation, leading to enhanced skin quality and tissue regeneration. Their relevance to healthspan is currently confined to improving the structural integrity and appearance of the skin, a key organ.

Purpose

Injectable biostimulator for skin regeneration and structural repair.

Card Summary

Injectable DNA fragments that promote skin regeneration and repair.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

3.5

Justification:

Primarily targets skin aesthetics with no proven systemic longevity benefits.

Evidence

Grade:

B

Score:

5.5

Justification:

Human trials exist but focus on aesthetic outcomes, not systemic healthspan.

Safety

Score:

3.8

Justification:

Generally well-tolerated but carries risks associated with any injection procedure.

Flags

• Primarily an aesthetic treatment; systemic healthspan benefits are speculative.
• Contraindicated for individuals with fish or salmon allergies.
• Requires a skilled practitioner for safe and effective administration.
• Results are temporary and require maintenance treatments.

Verdict

A promising aesthetic tool for skin rejuvenation, not a systemic intervention.

Created

2026-04-26T18:47:25.429968Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

none

Scope:

• local

Indication

Focus:

healthspan

Description:

Polynucleotides are purified DNA fragments, typically derived from salmon, that are injected into the skin. They act as signaling molecules to stimulate fibroblasts, promote collagen and elastin synth...

Typical Protocol

• A course of 2-3 injection sessions spaced 2-4 weeks apart, repeated annually.