Piperine

Piperine is the primary bioactive compound in black pepper, valued in healthspan protocols not for direct longevity effects but as a potent bioenhancer. It works by inhibiting key drug-metabolizing enzymes (like CYP3A4) and transporters in the gut and liver. This action significantly increases the bioavailability and systemic exposure of many other compounds, such as curcumin, resveratrol, and CoQ10, allowing for greater efficacy at lower doses.

Verdict

A valuable bioenhancer for specific supplements; check for drug interactions.

Protocol

• Take 5-10 mg once or twice daily with other supplements to enhance their absorption.

Flags

• Inhibits CYP450 enzymes, potentially increasing levels of many prescription drugs (e.g., statins, calcium channel blockers).
• Consult a physician before use if taking any prescription medication.
• May cause gastrointestinal discomfort in sensitive individuals.