Meta Information
ID:piperine
Name:Piperine
Schema Version:1.5
Alternate Names
- Black Pepper Extract
- Bioperine
Intervention Type
therapeutic_agent
Expected Cost Mean
Low Cost:
2
High Cost:
5
Cost Type:
monthly
Description:
Very low cost as a standalone supplement or additive.
Summary
Piperine is the primary bioactive compound in black pepper, valued in healthspan protocols not for direct longevity effects but as a potent bioenhancer. It works by inhibiting key drug-metabolizing enzymes (like CYP3A4) and transporters in the gut and liver. This action significantly increases the bioavailability and systemic exposure of many other compounds, such as curcumin, resveratrol, and CoQ10, allowing for greater efficacy at lower doses.
Purpose
A bioenhancer that increases absorption of other supplements.
Card Summary
A black pepper extract that significantly boosts the absorption and effectiveness of other supplements like curcumin and resveratrol.
Drug Class
Drugs In Class
Empty Array
Impact
Score:
4.2
Justification:
Primarily acts as a bioenhancer; its direct longevity impact is limited.
Evidence
Grade:
B
Score:
6.5
Justification:
Strong human data for bioavailability enhancement, less for direct healthspan effects.
Safety
Score:
3.8
Justification:
Generally safe, but significantly interacts with many common prescription medications.
Flags
- Inhibits CYP450 enzymes, potentially increasing levels of many prescription drugs (e.g., statins, calcium channel blockers).
- Consult a physician before use if taking any prescription medication.
- May cause gastrointestinal discomfort in sensitive individuals.
Verdict
A valuable bioenhancer for specific supplements; check for drug interactions.
Created
2026-04-26T03:20:47.703158Z
Model
Gemini 3.1 Pro (High)
Delivery
Route:
oral
Scope:
- systemic
Indication
Focus:
healthspan
Description:
Piperine is the primary bioactive compound in black pepper, valued in healthspan protocols not for direct longevity effects but as a potent bioenhancer. It works by inhibiting key drug-metabolizing en...
Typical Protocol
- Take 5-10 mg once or twice daily with other supplements to enhance their absorption.