Peppermint oil's primary active component, L-menthol, acts as a smooth muscle relaxant, particularly in the gastrointestinal tract. Its healthspan relevance is primarily indirect, focused on mitigating chronic gut discomfort associated with conditions like IBS, which can be a source of systemic stress and reduced quality of life. There is no direct evidence for its role in extending lifespan.
Verdict
Effective for IBS symptom relief, but not a core longevity agent.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Low
EVIDENCE GRADE
A
MONTHLY COST
$10 - $25
Protocol
- Take one enteric-coated capsule containing 180-200 mg of peppermint oil 1-3 times daily before meals for digestive support.
Flags
- Must be enteric-coated for oral use to avoid heartburn and esophageal irritation.
- May interfere with drugs metabolized by the CYP3A4 enzyme, such as cyclosporine.
- Can worsen symptoms of GERD (gastroesophageal reflux disease).
- Avoid in individuals with bile duct, liver, or gallbladder problems.