Meta Information

ID:peppermint-oil

Name:Peppermint Oil

Schema Version:1.5

Alternate Names

• Mentha piperita oil

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

10

High Cost:

25

Cost Type:

monthly

Description:

Widely available over-the-counter supplement for digestive health.

Summary

Peppermint oil's primary active component, L-menthol, acts as a smooth muscle relaxant, particularly in the gastrointestinal tract. Its healthspan relevance is primarily indirect, focused on mitigating chronic gut discomfort associated with conditions like IBS, which can be a source of systemic stress and reduced quality of life. There is no direct evidence for its role in extending lifespan.

Purpose

Reduces gut inflammation and discomfort, improving quality of life.

Card Summary

A natural smooth muscle relaxant primarily used to alleviate symptoms of Irritable Bowel Syndrome (IBS) and improve digestive comfort.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

3.5

Justification:

Symptomatic relief for gut issues; no direct evidence for lifespan extension.

Evidence

Grade:

A

Score:

8.5

Justification:

Multiple high-quality RCTs and meta-analyses confirm efficacy for IBS symptom relief.

Safety

Score:

3.2

Justification:

Generally recognized as safe (GRAS) but can cause heartburn or interact with medications.

Flags

• Must be enteric-coated for oral use to avoid heartburn and esophageal irritation.
• May interfere with drugs metabolized by the CYP3A4 enzyme, such as cyclosporine.
• Can worsen symptoms of GERD (gastroesophageal reflux disease).
• Avoid in individuals with bile duct, liver, or gallbladder problems.

Verdict

Effective for IBS symptom relief, but not a core longevity agent.

Created

2026-04-26T18:11:38.171546Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Peppermint oil's primary active component, L-menthol, acts as a smooth muscle relaxant, particularly in the gastrointestinal tract. Its healthspan relevance is primarily indirect, focused on mitigatin...

Typical Protocol

• Take one enteric-coated capsule containing 180-200 mg of peppermint oil 1-3 times daily before meals for digestive support.