Meta Information

ID:passionflower

Name:Passionflower

Schema Version:1.5

Alternate Names

• Passiflora incarnata
• maypop

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

10

High Cost:

25

Cost Type:

monthly

Description:

Widely available over-the-counter herbal supplement.

Summary

Passionflower is an herbal supplement primarily used for its anxiolytic (anxiety-reducing) and mild sedative properties. Its mechanism is thought to involve the modulation of the GABA neurotransmitter system, which promotes relaxation. From a healthspan perspective, its value is indirect, stemming from its potential to improve sleep quality and mitigate the physiological damage of chronic stress, both of which are linked to accelerated aging.

Purpose

Herbal supplement for improving sleep quality and reducing anxiety.

Card Summary

A mild herbal sedative that may improve sleep and reduce anxiety by modulating GABA.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

4.2

Justification:

Primarily addresses secondary health goals like sleep and anxiety, not core aging pathways.

Evidence

Grade:

B

Score:

6.5

Justification:

Some human RCTs and a meta-analysis support its use for anxiety and sleep.

Safety

Score:

3

Justification:

Generally recognized as safe (GRAS) with mild side effects, but potential sedative interactions.

Flags

• May cause drowsiness; avoid operating heavy machinery until effects are known.
• Potentiates effects of other sedatives, including alcohol, benzodiazepines, and barbiturates.
• Avoid during pregnancy and breastfeeding due to insufficient safety data.

Verdict

A reasonable, low-risk option for mild anxiety and sleep support.

Created

2026-04-26T17:46:25.176492Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Passionflower is an herbal supplement primarily used for its anxiolytic (anxiety-reducing) and mild sedative properties. Its mechanism is thought to involve the modulation of the GABA neurotransmitter...

Typical Protocol

• For anxiety, take 200-500 mg of standardized extract one to two times daily.
• For sleep, drink one cup of tea or take 400-800 mg of extract 30-60 minutes before bed.