Meta Information
ID:nr
Name:Nicotinamide Riboside
Schema Version:1.5
Alternate Names
- NR
- Niagen
Active Compound
nicotinamide riboside
Intervention Type
therapeutic_agent
Delivery
Route:
oral
Scope:
- systemic
Regulatory Status
- us:dietary_supplement
Indication
Focus:
healthspan
Description:
To increase systemic levels of NAD+, a critical coenzyme involved in cellular energy metabolism and DNA repair, which declines with age.
Typical Protocol
- Typical daily doses range from 300 mg to 1000 mg, taken orally.
Expected Cost Mean
Low Cost:
30
High Cost:
100
Cost Type:
monthly
Description:
Monthly cost for daily oral supplements; not covered by insurance.
Summary
Nicotinamide Riboside (NR) is a precursor to NAD+, a vital coenzyme for cellular energy and repair that declines with age. Supplementing with NR effectively increases NAD+ levels in humans. The central hypothesis is that restoring NAD+ can counteract age-related cellular dysfunction by improving mitochondrial function and enhancing DNA repair, thereby promoting healthspan.
Purpose
A vitamin B3 precursor that boosts cellular NAD+ levels.
Card Summary
A NAD+ precursor supplement intended to support cellular energy and repair.
Drug Class
null
Drugs In Class
Empty Array
Impact
Score:
3.5
Justification:
Effectively raises NAD+ levels, but downstream healthspan benefits in humans remain largely unproven.
Evidence
Grade:
B
Score:
5.5
Justification:
Human RCTs confirm it boosts NAD+, but evidence for clinical healthspan benefits is mixed.
Safety
Score:
3
Justification:
Generally Recognized As Safe (GRAS) status with mild, infrequent side effects in studies.
Flags
- Some preclinical data suggests high NAD+ levels could potentially promote growth of existing cancers.
- Long-term effects of chronic NAD+ elevation in healthy humans are unknown.
Verdict
Promising mechanism, but tangible healthspan benefits in humans are not yet proven.
Created
2026-05-05T22:01:05.560065Z
Ai Model
Gemini 2.5 Pro (High)