Meta Information
ID:nr
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/circadian/wake
Target name:
Waking Up
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
null
Hours after target:
2
Description:
Taking Nicotinamide Riboside in the morning aligns with the body's natural circadian rhythm of NAD+ production, which is highest during the day to support energy and activity.
Actionable advice:
Take your daily dose in the morning to support natural energy cycles.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
minor
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
4
Hours after target:
null
Description:
As a precursor to the energy-related molecule NAD+, taking Nicotinamide Riboside close to bedtime may be stimulating for some individuals and could potentially interfere with sleep onset.
Actionable advice:
Avoid taking Nicotinamide Riboside within 4 hours of your intended bedtime.
Target id:
/intervention/betaine
Target name:
Betaine (TMG)
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
The metabolism of NAD+ precursors like NR consumes methyl groups. Co-supplementing with a methyl donor like TMG helps replenish these groups, supporting healthy methylation cycles and preventing potential increases in homocysteine.
Actionable advice:
Consider taking a methyl donor like TMG, especially when using higher doses of Nicotinamide Riboside.
Target id:
/intervention/resveratrol
Target name:
Resveratrol
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
NR increases NAD+ levels, which acts as essential fuel for sirtuin enzymes. Resveratrol is a sirtuin-activating compound (STAC), so combining them may create a synergistic effect on cellular health and metabolism.
Actionable advice:
Consider taking Resveratrol alongside Nicotinamide Riboside to potentially enhance sirtuin activity.
Target id:
/intervention/pterostilbene
Target name:
Pterostilbene
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Pterostilbene, a compound similar to resveratrol, activates sirtuin enzymes. Combining it with NR, which provides the NAD+ fuel for sirtuins, may produce a synergistic effect on cellular health.
Actionable advice:
Consider taking Pterostilbene alongside Nicotinamide Riboside to potentially enhance sirtuin activity.
Target id:
/intervention/apigenin
Target name:
Apigenin
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Apigenin inhibits the CD38 enzyme, which is a primary consumer of NAD+. Combining it with NR, which boosts NAD+ production, creates a 'two-pronged' approach to increasing and maintaining cellular NAD+ levels.
Actionable advice:
Consider taking Apigenin with Nicotinamide Riboside to help preserve the NAD+ that is produced.
Target id:
/class/chemotherapy-radiation
Target name:
Cytotoxic Cancer Therapies (Chemotherapy & Radiation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Boosting NAD+ levels with NR may enhance cellular DNA repair and stress resistance pathways. This could theoretically reduce the effectiveness of chemotherapy and radiation, which rely on inducing damage in cancer cells.
Actionable advice:
Do not take Nicotinamide Riboside during active cancer treatment without explicit approval from your oncologist.
Target id:
/class/parp-inhibitors
Target name:
PARP Inhibitors
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
PARP inhibitors are cancer drugs that work by blocking an NAD+-dependent DNA repair enzyme. Supplementing with NR could increase NAD+ levels, potentially counteracting the therapeutic effect of these medications.
Actionable advice:
Avoid Nicotinamide Riboside completely if you are taking a PARP inhibitor medication for cancer.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The safety of high-dose Nicotinamide Riboside supplementation during pregnancy has not been established. It should be avoided out of an abundance of caution.
Actionable advice:
Do not take Nicotinamide Riboside supplements if you are pregnant.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is unknown if high doses of Nicotinamide Riboside or its metabolites pass into breast milk. Due to a lack of safety data, it should be avoided while breastfeeding.
Actionable advice:
Do not take Nicotinamide Riboside supplements if you are breastfeeding.
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Nicotinamide Riboside may improve insulin sensitivity and glucose control. When taken with medications for diabetes, this could have an additive effect, potentially increasing the risk of low blood sugar (hypoglycemia).
Actionable advice:
If you take diabetes medication, monitor your blood sugar closely when starting NR and consult your doctor.
Target id:
/condition/hepatic-impairment
Target name:
Hepatic Impairment
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Nicotinamide Riboside is metabolized by the body, involving the liver. In cases of severe liver impairment, metabolic capacity may be reduced, warranting caution and medical supervision.
Actionable advice:
Consult your doctor before taking Nicotinamide Riboside if you have significant liver disease.
Target id:
/intervention/nmn_systemic_healthspan
Target name:
NMN (Nicotinamide Mononucleotide)
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Both NR and NMN are precursors to NAD+ and function via similar pathways. Taking them together is redundant and unlikely to provide benefits beyond what an adequate dose of one alone would offer.
Actionable advice:
Choose either NR or NMN; taking both together is generally not necessary or cost-effective.
Target id:
/intervention/niacin
Target name:
Niacin (Vitamin B3)
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
NR and Niacin are both forms of Vitamin B3 that increase NAD+. Using them together is redundant for NAD+ boosting purposes and may increase the burden on metabolic pathways.
Actionable advice:
Use either NR or Niacin for NAD+ support, not both concurrently.
Target id:
/intervention/quercetin
Target name:
Quercetin
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Quercetin can inhibit the CD38 enzyme, a major consumer of cellular NAD+. Taking it with NR, an NAD+ precursor, may synergistically increase and sustain NAD+ levels.
Actionable advice:
Consider taking Quercetin with Nicotinamide Riboside to help preserve the NAD+ that is produced.
Target id:
/intervention/exercise
Target name:
Exercise
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Exercise naturally increases NAD+ levels and consumption. Supplementing with NR ensures an adequate supply of this crucial coenzyme to meet the metabolic demands of physical activity and support recovery.
Actionable advice:
Nicotinamide Riboside can be a supportive supplement to a regular exercise routine.
Target id:
/intervention/intermittent-fasting
Target name:
Intermittent Fasting
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Intermittent fasting is known to increase NAD+ levels. Taking NR during your eating window provides the building blocks to further enhance NAD+ pools, potentially amplifying the benefits.
Actionable advice:
Take Nicotinamide Riboside during your eating window when practicing intermittent fasting.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
While not required, taking Nicotinamide Riboside with a meal, particularly one containing some fat, may slightly enhance its absorption and can reduce the potential for mild stomach upset.
Actionable advice:
For potentially better absorption, take with a meal, but taking it on an empty stomach is also acceptable.
Target id:
/condition/renal-impairment
Target name:
Renal Impairment
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Metabolites of Nicotinamide Riboside are cleared by the kidneys. While no direct toxicity is known, caution is advised in severe kidney disease due to altered clearance.
Actionable advice:
Consult your doctor before using Nicotinamide Riboside if you have severe kidney disease.
Target id:
/intervention/levodopa
Target name:
Levodopa
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Preclinical research suggests that increasing NAD+ levels may support mitochondrial health and offer neuroprotective effects, which could theoretically complement the action of medications like Levodopa for Parkinson's disease.
Actionable advice:
Discuss with your neurologist before adding Nicotinamide Riboside to a Parkinson's disease treatment regimen.